Document Detail


Genomic and metabolomic patterns segregate with responses to calcium and vitamin D supplementation.
MedLine Citation:
PMID:  20727239     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Inter-individual response differences to vitamin D and Ca supplementation may be under genetic control through vitamin D and oestrogen receptor genes, which may influence their absorption and/or metabolism. Metabolomic studies on blood and urine from subjects supplemented with Ca and vitamin D reveal different metabolic profiles that segregate with genotype. Genotyping was performed for oestrogen receptor 1 gene (ESR1) and vitamin D receptor gene (VDR) in fifty-six postmenopausal women. Thirty-six women were classified as low bone density as determined by a heel ultrasound scan and twenty women had normal bone density acting as 'controls'. Those with low bone density (LBD) were supplemented with oral Ca and vitamin D and were classified according to whether they were 'responders' or 'non-responders' according to biochemical results before and after therapy compared to controls receiving no supplementation. Metabolomic studies on serum and urine were done for the three groups at 0 and 3 months of therapy using NMR spectroscopy with pattern recognition. The 'non-responder' group showed a higher frequency of polymorphisms in the ESR1 (codons 10 and 325) and VDR (Bsm1 and Taq1), compared with to the 'responders'. The wild-type genotype for Fok1 was more frequent in those with LBD (70 %) compared with the control group (10 %). Distinctive patterns of metabolites were displayed by NMR studies at baseline and 3 months of post-treatment, segregating responders from non-responders and controls. Identification of potential 'non-responders' to vitamin D and Ca, before therapy, based on a genomic and/or metabolomic profile would allow targeted selection of optimal therapy on an individual basis.
Authors:
Manal O Elnenaei; Rama Chandra; Tina Mangion; Caje Moniz
Related Documents :
22127969 - Ovarian reserve diminished by oral cyclophosphamide therapy for granulomatosis with pol...
18586649 - Dietary supplementation by older adults in japan.
18708389 - Salt and gastric adenocarcinoma: a population-based cohort study in norway.
6693579 - Selenium and vitamin e in relation to risk factors for coronary heart disease.
20955219 - Vitamin d deficiency prevalence and cardiovascular risk in israel.
18469269 - Dietary flavonoid intake and non-hodgkin lymphoma risk.
22295089 - Cutaneous larva migrans among devotees of the nallur temple in jaffna, sri lanka.
22261689 - Association of interleukin-6 circulating levels with coronary artery disease: a meta-an...
12880539 - Apolipoprotein e gene polymorphisms in patients with premature myocardial infarction: a...
Publication Detail:
Type:  Journal Article     Date:  2010-08-23
Journal Detail:
Title:  The British journal of nutrition     Volume:  105     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  71-9     Citation Subset:  IM    
Affiliation:
Clinical Biochemistry Department, King's College Hospital, Denmark Hill, London SE5 9RS, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gold kiwifruit consumed with an iron-fortified breakfast cereal meal improves iron status in women w...
Next Document:  Supplemental ?-carotene increases IgA-secreting cells in mammary gland and IgA transfer from milk to...