| Genomic medicine: bringing biomarkers to clinical medicine. | |
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MedLine Citation:
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PMID: 16006183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An important by-product of sequencing the human genome has been the development of a novel 'toolbox' for biomarker discovery and development. Genomic medicine is an emerging discipline in the genome sciences that integrates these tools to interrogate genomic variation in well-defined populations in order to develop predictors of disease susceptibility, progression and drug response. Several important classes of biomarkers result from these analyses which, when translated to clinical medicine and drug development, will have an important impact on human health and disease. This review highlights both the opportunities and challenges in bringing biomarkers into clinical medicine. |
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Authors:
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David Seo; Geoffrey S Ginsburg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in chemical biology Volume: 9 ISSN: 1367-5931 ISO Abbreviation: Curr Opin Chem Biol Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-25 Completed Date: 2005-11-01 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 9811312 Medline TA: Curr Opin Chem Biol Country: England |
Other Details:
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Languages: eng Pagination: 381-6 Citation Subset: IM |
Affiliation:
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Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Medicine
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methods*,
trends* Genetic Markers* Genomics / trends* Humans Pharmacogenetics / trends |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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