| Genomic instability and cancer: lessons from analysis of Bloom's syndrome. | |
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MedLine Citation:
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PMID: 19442250 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bloom's syndrome (BS) is a rare autosomal recessive disorder characterized by genomic instability and cancer predisposition. The underlying genetic defect is mutation of the BLM gene, producing deficiency in the RecQ helicase BLM (Bloom's syndrome protein). The present article begins by introducing BLM and its binding partners before reviewing its known biochemical activities and its potential roles both as a pro-recombinase and as a suppressor of homologous recombination. Finally, the evidence for an emerging role in mitotic chromosome segregation is examined. |
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Authors:
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Miranda Payne; Ian D Hickson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical Society transactions Volume: 37 ISSN: 1470-8752 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-15 Completed Date: 2009-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 553-9 Citation Subset: IM |
Affiliation:
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Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bloom Syndrome
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genetics*,
metabolism DNA Breaks, Double-Stranded DNA Repair Genomic Instability* Humans Mitosis / genetics Models, Genetic Mutation Neoplasms / genetics*, metabolism Protein Binding RecQ Helicases / genetics*, metabolism Recombination, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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//Cancer Research UK |
| Chemical | |
Reg. No./Substance:
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EC 3.6.1.-/Bloom syndrome protein; EC 3.6.1.-/RecQ Helicases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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