Document Detail

Genomic imprinting: lessons from mouse transgenes.
MedLine Citation:
PMID:  7514718     Owner:  NLM     Status:  MEDLINE    
Genomic imprinting is a non-Mendelian form of inheritance that results in an expression difference between the two parental alleles of an autosomal locus. The study of mouse transgenes has provided us with descriptions of a variety of imprinting or parent-of-origin effects, thereby anticipating similar inheritance phenomena in non-transgenic mice. Many mouse transgenes exhibit parent-of-origin behavior only on mixed strain backgrounds, whereas others are imprinted on inbred strain backgrounds. In the former cases, the parent-of-origin effects are due to strain-specific modifiers of DNA methylation and expression. These are inherited in a parent-specific fashion and exert their effects after fertilization. In the latter cases, true germline transgene imprinting, the creation of an imprinted locus occurs in a series of sequential steps. First, there is an erasure of the imprint from the previous generation in both male and female fetal germ cells. Second, upon completion of gametogenesis, distinctive methylation patterns have been placed on the transgene sequences of the two mature gametes. Third, only one of these inherited patterns is maintained in the early, pre-implantation embryo. The pattern of the other parental allele is erased. Finally, the methylation pattern of the alleles evolve in the later stages of development, but nonetheless the methylation difference (imprint) of the locus persists. Transgene imprinting behaviors, either on mixed strain backgrounds and on inbred genetic backgrounds, have counterparts in endogenous genetic phenomena.
J R Chaillet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Mutation research     Volume:  307     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-06-22     Completed Date:  1994-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  441-9     Citation Subset:  IM    
Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115.
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MeSH Terms
DNA / metabolism
Gene Expression Regulation*
Mice, Transgenic / genetics*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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