| Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a. | |
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MedLine Citation:
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PMID: 20212164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A defect in the maternal copy of a ubiqutin ligase gene Ube3a can produce a neurodevelopmental defect in human children known as Angelman syndrome. We investigated the role of the maternally expressed Ube3a gene in experience-dependent development and plasticity of the mouse visual system. As demonstrated by optical imaging, rapid ocular dominance (OD) plasticity after brief monocular deprivation (MD) was severely impaired during the critical period (CP) in the visual cortex (VC) of Ube3a maternal-deficient (m-/p+) mice. Prolonged MD elicited significant plasticity in m-/p+ mice that never matched the level seen in control animals. In older animals after the CP, 7-day MD elicited mild OD shifts in both control and m-/p+ mice; however, the OD shifts in m-/p+ mice lacked the strengthening of visual responses to the two eyes characteristic of normal adult plasticity. Anatomic effects of the maternal deficiency include reduced spine density on basal, but not apical, dendrites of pyramidal neurons in the binocular region of the VC. Imprinting of Ube3a expression was not fully established in the early postnatal period, consistent with the normal development of cortical retinotopy and visual acuity that we observed in m-/p+ mice, but was fully established by the onset of the CP. These results demonstrate that paternal and maternal genomes are not functionally equivalent for cortical plasticity, and that maternally expressed Ube3a is required for normal experience-dependent modification of cortical circuits during and after the CP. |
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Authors:
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Masaaki Sato; Michael P Stryker |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-03-08 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-24 Completed Date: 2010-04-16 Revised Date: 2010-09-24 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 5611-6 Citation Subset: IM |
Affiliation:
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W.M. Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, CA 94143-0444, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angelman Syndrome
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genetics,
physiopathology Animals Dominance, Ocular / genetics, physiology Female Genomic Imprinting* Humans Male Mice Mice, Inbred C57BL Mice, Knockout Neuronal Plasticity / genetics, physiology Ubiquitin-Protein Ligases / deficiency, genetics*, physiology Visual Cortex / growth & development, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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EY02874/EY/NEI NIH HHS; MH077972/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 6.3.2.19/Ube3a protein, mouse; EC 6.3.2.19/Ubiquitin-Protein Ligases |
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