| Genomic gems: SINE RNAs regulate mRNA production. | |
| | |
MedLine Citation:
|
PMID: 20176473 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mammalian short interspersed elements (SINEs) are abundant retrotransposons that have long been considered junk DNA; however, RNAs transcribed from mouse B2 and human Alu SINEs have recently been found to control mRNA production at multiple levels. Upon cell stress B2 and Alu RNAs bind RNA polymerase II (Pol II) and repress transcription of some protein-encoding genes. Bi-directional transcription of a B2 SINE establishes a boundary that places the growth hormone locus in a permissive chromatin state during mouse development. Alu RNAs embedded in Pol II transcripts can promote evolution and proteome diversity through exonization via alternative splicing. Given the diverse means by which SINE encoded RNAs impact production of mRNAs, this genomic junk is proving to contain hidden gems. |
| | |
Authors:
|
Steven L Ponicsan; Jennifer F Kugel; James A Goodrich |
Related Documents
:
|
20589163 - Multi-talented dead-box proteins and potential tumor promoters: p68 rna helicase (ddx5)... 19965463 - Subcellular mrna localization in animal cells and why it matters. 21823023 - Inhibition of melanoma cell proliferation by targeting wnt/β-catenin pathway through s... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-02-20 |
Journal Detail:
|
Title: Current opinion in genetics & development Volume: 20 ISSN: 1879-0380 ISO Abbreviation: Curr. Opin. Genet. Dev. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-26 Completed Date: 2010-08-10 Revised Date: 2011-07-27 |
Medline Journal Info:
|
Nlm Unique ID: 9111375 Medline TA: Curr Opin Genet Dev Country: England |
Other Details:
|
Languages: eng Pagination: 149-55 Citation Subset: IM |
Copyright Information:
|
2010 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Chemistry and Biochemistry, University of Colorado, Boulder, 80309-0215, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alu Elements
/
genetics Animals Gene Expression Regulation* Humans Models, Genetic RNA / genetics* RNA, Messenger / genetics*, metabolism Short Interspersed Nucleotide Elements / genetics* Transcription, Genetic |
| Grant Support | |
ID/Acronym/Agency:
|
R01 GM068414/GM/NIGMS NIH HHS; R01 GM068414-07/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/RNA, Messenger; 63231-63-0/RNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Screening DNA-targeted anticancer drug in vitro based on the drug-conjugated DNA by resonance light ...
Next Document: Telomere rejuvenation during nuclear reprogramming.