Document Detail


Genomic evidence for elevated mutation rates in highly expressed genes.
MedLine Citation:
PMID:  23146897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reporter gene assays have demonstrated both transcription-associated mutagenesis (TAM) and transcription-coupled repair, but the net impact of transcription on mutation rate remains unclear, especially at the genomic scale. Using comparative genomics of related species as well as mutation accumulation lines, we show in yeast that the rate of point mutation in a gene increases with the expression level of the gene. Transcription induces mutagenesis on both DNA strands, indicating simultaneous actions of several TAM mechanisms. A significant positive correlation is also detected between the human germline mutation rate and expression level. These results indicate that transcription is overall mutagenic.
Authors:
Chungoo Park; Wenfeng Qian; Jianzhi Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-13
Journal Detail:
Title:  EMBO reports     Volume:  13     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-05-30     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  1123-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Gene Expression Regulation*
Genome, Fungal
Germ-Line Mutation
Humans
Mutagenesis
Mutation Rate*
Point Mutation / genetics*
Saccharomyces cerevisiae / genetics*
Transcription, Genetic
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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