| Genomic anatomy of the hippocampus. | |
| | |
MedLine Citation:
|
PMID: 19109908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Availability of genome-scale in situ hybridization data allows systematic analysis of genetic neuroanatomical architecture. Within the hippocampus, electrophysiology and lesion and imaging studies demonstrate functional heterogeneity along the septotemporal axis, although precise underlying circuitry and molecular substrates remain uncharacterized. Application of unbiased statistical component analyses to genome-scale hippocampal gene expression data revealed robust septotemporal molecular heterogeneity, leading to the identification of a large cohort of genes with robust regionalized hippocampal expression. Manual mapping of heterogeneous CA3 pyramidal neuron expression patterns demonstrates an unexpectedly complex molecular parcellation into a relatively coherent set of nine expression domains in the septal/temporal and proximal/distal axes with reciprocal, nonoverlapping boundaries. Unique combinatorial profiles of adhesion molecules within these domains suggest corresponding differential connectivity, which is demonstrated for CA3 projections to the lateral septum using retrograde labeling. This complex, discrete molecular architecture provides a novel paradigm for predicting functional differentiation across the full septotemporal extent of the hippocampus. |
| | |
Authors:
|
Carol L Thompson; Sayan D Pathak; Andreas Jeromin; Lydia L Ng; Cameron R MacPherson; Marty T Mortrud; Allison Cusick; Zackery L Riley; Susan M Sunkin; Amy Bernard; Ralph B Puchalski; Fred H Gage; Allan R Jones; Vladimir B Bajic; Michael J Hawrylycz; Ed S Lein |
Related Documents
:
|
12783628 - Easygene--a prokaryotic gene finder that ranks orfs by statistical significance. 19910308 - Edger: a bioconductor package for differential expression analysis of digital gene expr... 18464328 - Analysis of nonlinear relations between expression profiles by the principal curves of ... 20153338 - Essential molecular functions associated with the circular code evolution. 7580858 - Adenosine diphosphate glucose pyrophosphorylase genes in wheat: differential expression... 11055398 - Gene regulation in response to overexpression of cytochrome p450 and proliferation of t... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuron Volume: 60 ISSN: 1097-4199 ISO Abbreviation: Neuron Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-12-26 Completed Date: 2009-04-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
|
Languages: eng Pagination: 1010-21 Citation Subset: IM |
Affiliation:
|
Allen Institute for Brain Science, Seattle, WA 98103, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Newborn Brain Mapping* Cholera Toxin / metabolism Gene Expression Regulation, Developmental / physiology* Genomics* Hippocampus / anatomy & histology*, physiology* Imaging, Three-Dimensional In Situ Hybridization / methods Male Mice Mice, Inbred C57BL Models, Biological Nerve Tissue Proteins / genetics, metabolism Neural Cell Adhesion Molecules / genetics, metabolism Neural Pathways / anatomy & histology, metabolism Principal Component Analysis Septum Pellucidum / anatomy & histology, metabolism Temporal Lobe / anatomy & histology, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Nerve Tissue Proteins; 0/Neural Cell Adhesion Molecules; 9012-63-9/Cholera Toxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes a...
Next Document: Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal acti...