Document Detail


Genomic-anatomic evidence for distinct functional domains in hippocampal field CA1.
MedLine Citation:
PMID:  19561297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Functional heterogeneity has been investigated for decades in the hippocampal region of the mammalian cerebral cortex, and evidence for vaguely defined "dorsal" and "ventral" regions is emerging. Direct evidence that hippocampal field CA1 displays clear regional, laminar, and pyramidal neuron differentiation is presented here, based on a systematic high-resolution analysis of a publicly accessible, genome-wide expression digital library (Allen Brain Atlas) [Lein et al. (2007) Genome-wide atlas of gene expression in the adult mouse brain. Nature 445:168-176]. First, genetic markers reveal distinct spatial expression domains and subdomains along the longitudinal (dorsal/septal/posterior to ventral/temporal/anterior) axis of field CA1. Second, genetic markers divide field CA1 pyramidal neurons into multiple subtypes with characteristic laminar distributions. And third, subcortical brain regions receiving axonal projections from molecularly distinct spatial domains of field CA1 display distinct global gene expression patterns, suggesting that field CA1 spatial domains may be genetically wired independently to form distinct functional networks related to cognition and emotion. Insights emerging from this genomic-anatomic approach provide a starting point for a detailed analysis of differential hippocampal structure-function organization.
Authors:
Hong-Wei Dong; Larry W Swanson; Lin Chen; Michael S Fanselow; Arthur W Toga
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-06-26
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  106     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-20     Completed Date:  2009-09-09     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11794-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping
Cell Differentiation / physiology
Gene Expression Profiling / methods*
Gene Library
Hippocampus / anatomy & histology*,  metabolism*
Mice
Pyramidal Cells / cytology*
Grant Support
ID/Acronym/Agency:
MH083180/MH/NIMH NIH HHS; MH62122/MH/NIMH NIH HHS; NS16686/NS/NINDS NIH HHS; P41 RR013642/RR/NCRR NIH HHS; R01 MH062122/MH/NIMH NIH HHS; R01 NS016686/NS/NINDS NIH HHS; R21 MH083180/MH/NIMH NIH HHS; RR013642/RR/NCRR NIH HHS
Comments/Corrections

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