Document Detail


Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors.
MedLine Citation:
PMID:  17331038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the viral features of long-term nonprogressive HIV-1 infection and the selection of viral genomes, we studied serial complete HIV-1 sequences obtained from a mother-child pair, both long-term nonprogressors. Analysis of four genomic sequences demonstrated that all viral genes were intact, lacking major deletions or premature stop codons to easily explain the slow disease progression. These data suggest that viral attenuation, if present, was caused by subtle sequence variations or virus-host interactions. Serial sequences from an HIV-1-infected mother-child pair afforded us the opportunity to examine the immune selection of HIV-1 sequences years after transmission between individuals. We demonstrated that the daughter's strains were most likely subjected to immunoselection or immunoediting according to the presence of novel MHC class I alleles that differed between mother and daughter. An analysis of nef-specific cytotoxic T-lymphocyte responses in the child, whose HIV-1 nef sequence differed from the maternal nef, supported this interpretation. This study highlights the potential of full genome analysis in the investigation of pathogenesis and immune selection during HIV-1 evolution.
Authors:
Milan Reinis; Barbara Weiser; Carla Kuiken; Tao Dong; Dorothy Lang; Sharon Nachman; Yonghong Zhang; Sarah Rowland-Jones; Harold Burger
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  23     ISSN:  0889-2229     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-02     Completed Date:  2007-04-19     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  309-15     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Adult
Child, Preschool
Disease Progression
Evolution, Molecular*
Female
Gene Products, nef / chemistry
Genes, MHC Class I
HIV Infections / genetics*
HIV Long-Term Survivors*
HIV-1 / genetics*
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical*
Molecular Sequence Data
Pregnancy
Retroviridae Proteins / chemistry
Selection, Genetic
nef Gene Products, Human Immunodeficiency Virus
Grant Support
ID/Acronym/Agency:
D43 TW 000233/TW/FIC NIH HHS; D43 TW000233/TW/FIC NIH HHS; D43 TW000233-06/TW/FIC NIH HHS; MC_U137884180//Medical Research Council; R01 AI 42555/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Gene Products, nef; 0/Retroviridae Proteins; 0/nef Gene Products, Human Immunodeficiency Virus
Comments/Corrections

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