Document Detail

Genomic aberrations and survival in cutaneous T cell lymphomas.
MedLine Citation:
PMID:  15086538     Owner:  NLM     Status:  MEDLINE    
Information on chromosomal aberrations in cutaneous T cell lymphomas (CTCL), is scarce. In this study, comparative genomic hybridization (CGH) was used to analyze chromosomal imbalances (CI) in 32 patients with CTCL. CI were detected in 21 patients (66%). Euchromatic loss (dim) was localized most frequently (>16%) at the chromosomal regions 17p (28%), 13q (25%), 10q (16%), and 6q (19%), and gain of chromatin (enh) at 7 (25%), 8q (25%), and 17q (16%). The pattern dim6q-enh7-enh8-dim13 was the most frequent combination of CI. The number of aberrations per tumor sample varied between 0 and 19 and correlated with clinical tumor stages: from none in stage Ia to 8.75+/-1.8 (mean+/-SEM) in stage IVa. CI occurred more frequently in aggressive subtypes (9.33+/-2.16) than in indolent (2.88+/-0.8) subtypes. A high number of CI (>/=5) was associated with shorter survival. Gain of chromatin in 8q and loss of 6q and 13q correlated with a significantly shorter survival, whereas the most frequently observed aberrations (loss in 17p and gain in 7) did not influence the prognosis. In summary, CGH analysis revealed a characteristic pattern of recurring chromosomal gains and losses in CTCL. The association of the imbalances with the clinical course of the disease suggests that genes encoded at these loci may influence tumor development and progression.
Tanja C Fischer; Sylke Gellrich; J Marcus Muche; Tumenjargal Sherev; Heike Audring; Heidemarie Neitzel; Peter Walden; Wolfram Sterry; Holger Tönnies
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  122     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-16     Completed Date:  2004-05-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  579-86     Citation Subset:  IM    
Department of Dermatology, Charite, Humboldt University, Berlin, Germany.
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MeSH Terms
Chromosome Aberrations*
Lymphoma, T-Cell, Cutaneous / genetics*,  mortality,  pathology
Middle Aged
Neoplasm Staging
Skin Neoplasms / genetics*,  mortality,  pathology
Survival Rate

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