Document Detail

Genomic Risk Variants at 1p13.3, 1q41 and 3q22.3 are Associated with Subsequent Cardiovascular Outcomes in Healthy Controls and in Established Coronary Artery Disease.
MedLine Citation:
PMID:  21984477     Owner:  NLM     Status:  Publisher    
BACKGROUND: -Genome-wide associations studies (GWAS) have identified gene variants associated with coronary artery disease risk, however, whether they impact on disease progression is largely unknown. This study investigated associations between polymorphisms at 1p13.3 (rs599839), 1q41 (rs17465637) and 3q22.3 (rs9818870) and cardiovascular outcomes in healthy volunteers and in patients with established heart disease. METHODS AND RESULTS: -Healthy Volunteer participants (HV, n=1649), Coronary Disease Cohort Study (CDCS, n=1797) and Post-Myocardial Infarction (PMI, n=906) study participants (New Zealand), were genotyped for rs599839, rs9818870 and rs17465637. Associations between genotype and anthropometric characteristics, neurohormonal analysis, echocardiography and clinical outcomes over medium-long term follow-up (median HV=5.9 yrs, CDCS=3.7 yrs, PMI=11.3 yrs) were tested. At 1p13.3, HV and CDCS participants carrying 1 or more rs599839'G' allele had a lower prevalence of dyslipidemia (p≤0.005), or lower LDL (p=0.031) and total cholesterol (p=0.004), and/or less history of myocardial infarction (p≤0.04) compared with 'AA' participants. Moreover, CDCS and PMI 'AG/GG' patients had better cardiac function as indicated by echocardiography (p≤0.026), and fewer CDCS 'AG/GG' patients were readmitted for a non ST-elevation MI (p=0.012) during follow-up. 1q41 (rs17465637) was associated with better cardiovascular outcomes in the HV (p=0.028) and PMI (p=0.008) cohorts, and 3q22.3 (rs9818870) was a predictor of death/admission in the HV cohort (p=0.045). CONCLUSIONS: -These data suggest that coronary artery disease genomic risk variants at 1p13.3 and 1q41 are associated with subsequent clinical outcome in heart patients, and confirm rs9818870 at 3q22.3 as a predictor of cardiovascular risk in individuals free of overt heart disease.
Katrina L Ellis; Chris M Frampton; Anna P Pilbrow; Richard W Troughton; Rob N Doughty; Gillian A Whalley; Chris J Ellis; Lorraine Skelton; Judith Thomson; Tim G Yandle; A Mark Richards; Vicky A Cameron
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-7
Journal Detail:
Title:  Circulation. Cardiovascular genetics     Volume:  -     ISSN:  1942-3268     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101489144     Medline TA:  Circ Cardiovasc Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 University of Otago-Christchurch, Christchurch, New Zealand, New Zealand;
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