Document Detail


Genomic DNA sequence of Rhesus (M. mulatta) cystic fibrosis (CFTR) gene.
MedLine Citation:
PMID:  9530627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cystic fibrosis is a common human genetic disease caused by mutations in CFTR, a gene that codes for a chloride channel that is regulated by phosphorylation and cytosolic nucleotides. As part of a program to discover natural animal models for human genetic diseases, we have determined the genomic sequence of CFTR in the Rhesus monkey, Macaca mulatta. The coding region of rhesus CFTR is 98.3% identical to human CFTR at the nucleotide level and 98.2% identical and 99.7% similar at the amino acid level. Partial sequences of flanking introns (5582 base pair positions analyzed) revealed 91.1% identity with human introns. Relative to rhesus intronic sequence, the human sequences had 27 insertions and 22 deletions. Primer sequences for amplification of rhesus genomic CFTR sequences are provided. The accession number is AF013753 (all 27 exons and some flanking intronic sequence).
Authors:
J J Wine; D Glavac; G Hurlock; C Robinson; M Lee; U Potocnik; M Ravnik-Glavac; M Dean
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mammalian genome : official journal of the International Mammalian Genome Society     Volume:  9     ISSN:  0938-8990     ISO Abbreviation:  Mamm. Genome     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-05-22     Completed Date:  1998-05-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9100916     Medline TA:  Mamm Genome     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-5     Citation Subset:  IM    
Affiliation:
Cystic Fibrosis Research Laboratory, Stanford University, California 94305-2130, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF013753;  AF016924;  AF016925;  AF016926;  AF016927;  AF016928;  AF016929;  AF016930;  AF016931;  AF016932;  AF016933;  AF016934;  AF016935;  AF016936;  AF016937;  AF016938;  AF016939;  AF016940;  AF016941;  AF016942;  AF016943;  AF016944;  AF016945;  AF016946;  AF016947;  AF016948;  AF016949;  AF016950
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Cystic Fibrosis Transmembrane Conductance Regulator / genetics*
DNA / genetics*
Humans
Introns
Macaca mulatta / genetics*
Molecular Sequence Data
RNA Splicing
Repetitive Sequences, Nucleic Acid
Sequence Homology, Nucleic Acid
Grant Support
ID/Acronym/Agency:
HL51776/HL/NHLBI NIH HHS; RR00169/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/CFTR protein, human; 126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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