Document Detail


Genomewide cDNA microarray screening of genes related to benefits and toxicities of platinum-based chemotherapy in patients with advanced lung cancer.
MedLine Citation:
PMID:  16062078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors conducted a study using cDNA microarray analysis to determine whether expression levels of genes in tumors were correlated with the outcome of chemotherapy. Forty-seven patients were studied, and all except 3 received platinum-based chemotherapy. The expression levels of 1176 genes in transbronchial biopsy specimens of tumors that were obtained before chemotherapy were analyzed using the Atlas Human Cancer 1.2 Array. Multivariate regression analysis revealed that 3 genes were each independent factors related to tumor resistance to chemotherapy and patient survival (P < 0.01). Among various chemotherapy-related toxicities, 1, 3, 3, 1, and 1 genes were also revealed to be independent factors that were correlated with neutropenia, anemia, diarrhea, infection, and increased serum creatinine respectively (P < 0.01). It is concluded that not only the benefits but also the toxicities of chemotherapy can be predicted by cDNA microarray using tumor specimens obtained before chemotherapy.
Authors:
Fumihiro Oshita; Mizuki Ikehara; Akiko Sekiyama; Nobuyuki Hamanaka; Haruhiro Saito; Kouzo Yamada; Kazumasa Noda; Yoichi Kameda; Yohei Miyagi
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of clinical oncology     Volume:  28     ISSN:  1537-453X     ISO Abbreviation:  Am. J. Clin. Oncol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-02     Completed Date:  2005-11-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8207754     Medline TA:  Am J Clin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  367-70     Citation Subset:  IM    
Affiliation:
Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan. foshita@kcch.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anemia / blood,  chemically induced,  genetics
Antineoplastic Agents / adverse effects*,  therapeutic use*
Carcinoma, Non-Small-Cell Lung / drug therapy,  genetics
Carcinoma, Small Cell / drug therapy,  genetics
Creatinine / blood
Diarrhea / blood,  chemically induced,  genetics
Female
Gene Expression
Genetic Testing / methods*
Humans
Infection / blood,  chemically induced,  genetics
Lung Neoplasms / drug therapy*,  genetics*
Male
Middle Aged
Multivariate Analysis
Neutropenia / blood,  chemically induced,  genetics
Oligonucleotide Array Sequence Analysis / methods
Platinum Compounds / adverse effects*,  therapeutic use*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Platinum Compounds; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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