Document Detail

Genomewide association studies in allergy and the influence of ethnicity.
MedLine Citation:
PMID:  20724922     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Asthma and allergic diseases are common and disproportionately affect racial and ethnic minorities. Large-scale research efforts and the expense committed to multiple genomewide association studies (GWAS) have led to the identification of numerous susceptibility loci for the allergic diseases, but few successes have been reported in populations that are not of European ancestry.
RECENT FINDINGS: Of the more than two dozen GWAS for asthma and allergic disease performed to date, very few have included racial/ethnic minorities. Lessons learned from the studies conducted so far suggest that the GWAS approach must include considerations unique to the ancestral populations represented in the sample, population stratification due to admixture, and recognition that the current coverage of common variants both in the public database and on commercially available single-nucleotide polymorphism chips is inadequate to detect true genetic associations among ethnic/racial groups.
SUMMARY: Advancements in the GWAS technology for identifying genes relevant to asthma and allergic disease among under-represented ethnic and racial minorities who suffer most will facilitate the identification and confirmation of validated genetic risk factors that are both unique to minority groups as well as confirm risk factors that are generic to the population at large.
Kathleen C Barnes
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  10     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-25     Completed Date:  2011-03-15     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-33     Citation Subset:  IM    
Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA.
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MeSH Terms
Databases, Genetic
Ethnic Groups*
European Continental Ancestry Group
Genetic Predisposition to Disease
Genome-Wide Association Study
Hypersensitivity / epidemiology,  genetics*
Minority Groups*
Polymorphism, Single Nucleotide
Risk Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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