| Genome-wide search for genes affecting serum uric acid levels: the Framingham Heart Study. | |
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MedLine Citation:
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PMID: 16253630 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum uric acid levels are associated with hypertension, cardiovascular disease, and renal disease. Uric acid has been shown to be heritable; however, genome-wide linkage analyses have not been reported. Genome-wide multipoint variance components linkage analyses with 401 markers spaced at approximately 10 centimorgan (cM) were conducted on 1258 subjects of the Framingham Heart Study, using the average of two serum uric acid measurements obtained in examinations 1 and 2 around 1971 and 1979. Covariates in fully adjusted model included sex, age, body mass index (BMI), serum creatinine, alcohol consumption, diabetes, diuretic treatment, and triglycerides. To investigate possible pleiotropic effects between uric acid and covariates that may have a genetic component, bivariate linkage analyses of uric acid with BMI, triglycerides, and glucose were conducted at the uric acid linkage regions. The heritability of uric acid was 0.63. The highest multipoint log-of-the-odds (LOD) score was 3.3 at 50 cM on chromosome 15 for age-sex-adjusted uric acid, but decreased to 1.5 after multivariable adjustment. Additional evidence of linkage was seen on chromosomes 2 (LOD score 1.1 at 4 cM) and 8 (LOD score 1.7 at 6 cM) for multivariable-adjusted uric acid. Pleiotropic effects were only found between uric acid and glucose and BMI at chromosomes 8 and 15 linkage locations, respectively. We have identified several novel loci linked to uric acid. We found possible pleiotropic effects between uric acid and BMI and glucose. Further research is necessary to identify the genes involved in uric acid metabolism and their roles in hypertension, cardiovascular disease, and renal disease. |
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Authors:
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Qiong Yang; Chao-Yu Guo; L Adrienne Cupples; Daniel Levy; Peter W F Wilson; Caroline S Fox |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 54 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-28 Completed Date: 2005-12-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 1435-41 Citation Subset: IM |
Affiliation:
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Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA. qyang@bu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiovascular Diseases / genetics*, metabolism* Chromosomes, Human* Chromosomes, Human, Pair 15 Chromosomes, Human, Pair 2 Chromosomes, Human, Pair 8 Cohort Studies Female Genome, Human* Genomics Humans Linkage (Genetics) Male Massachusetts Middle Aged Uric Acid / blood* |
| Grant Support | |
ID/Acronym/Agency:
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N01-HC-25195/HC/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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