Document Detail


Genome-wide linkage scan for quantitative trait loci underlying normal variation in heel bone ultrasound measures.
MedLine Citation:
PMID:  22237995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantitative ultrasound (QUS) traits are correlated with bone mineral density (BMD), but predict risk for future fracture independent of BMD. Only a few studies, however, have sought to identify specific genes influencing calcaneal QUS measures. The aim of this study was to conduct a genome-wide linkage scan to identify quantitative trait loci (QTL) influencing normal variation in QUS traits. QUS measures were collected from a total of 719 individuals (336 males and 383 females) from the Fels Longitudinal Study who have been genotyped and have at least one set of QUS measurements. Participants ranged in age from 18.0 to 96.6 years and were distributed across 110 nuclear and extended families. Using the Sahara ® bone sonometer, broadband ultrasound attenuation (BUA), speed of sound (SOS) and stiffness index (QUI) were collected from the right heel. Variance components based linkage analysis was performed on the three traits using 400 polymorphic short tandem repeat (STR) markers spaced approximately 10 cM apart across the autosomes to identify QTL influencing the QUS traits. Age, sex, and other significant covariates were simultaneously adjusted. Heritability estimates (h²) for the QUS traits ranged from 0.42 to 0.57. Significant evidence for a QTL influencing BUA was found on chromosome 11p15 near marker D11S902 (LOD = 3.11). Our results provide additional evidence for a QTL on chromosome 11p that harbors a potential candidate gene(s) related to BUA and bone metabolism.
Authors:
M Lee; A C Choh; K D Williams; V Schroeder; T D Dyer; J Blangero; S A Cole; Wm C Chumlea; D L Duren; R J Sherwood; R M Siervogel; B Towne; S A Czerwinski
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The journal of nutrition, health & aging     Volume:  16     ISSN:  1760-4788     ISO Abbreviation:  J Nutr Health Aging     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-12     Completed Date:  2012-06-13     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  100893366     Medline TA:  J Nutr Health Aging     Country:  France    
Other Details:
Languages:  eng     Pagination:  8-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bone Density / genetics*
Calcaneus / ultrasonography*
Chromosomes, Human, Pair 11*
Family
Female
Genetic Linkage*
Genetic Markers
Genetic Variation*
Genome
Genotype
Humans
Longitudinal Studies
Male
Microsatellite Repeats
Middle Aged
Quantitative Trait Loci*
Quantitative Trait, Heritable
Reference Values
Young Adult
Grant Support
ID/Acronym/Agency:
AR52147/AR/NIAMS NIH HHS; HD12252/HD/NICHD NIH HHS; R01 AR052147/AR/NIAMS NIH HHS; R01 HD012252/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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