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Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
MedLine Citation:
PMID:  23042114     Owner:  NLM     Status:  Publisher    
Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P(combined) = 8.36 × 10(-18)), the major histocompatibility complex (MHC) region (P = 8.38 × 10(-20)), OR10A3-NLRP10 (P = 1.54 × 10(-22)), GLB1 (P = 2.77 × 10(-16)), CCDC80 (P = 1.56 × 10(-19)), CARD11 (P = 7.83 × 10(-9)), ZNF365 (P = 5.85 × 10(-20)) and CYP24A1-PFDN4 (P = 1.65 × 10(-8)). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.
Tomomitsu Hirota; Atsushi Takahashi; Michiaki Kubo; Tatsuhiko Tsunoda; Kaori Tomita; Masafumi Sakashita; Takechiyo Yamada; Shigeharu Fujieda; Shota Tanaka; Satoru Doi; Akihiko Miyatake; Tadao Enomoto; Chiharu Nishiyama; Nobuhiro Nakano; Keiko Maeda; Ko Okumura; Hideoki Ogawa; Shigaku Ikeda; Emiko Noguchi; Tohru Sakamoto; Nobuyuki Hizawa; Koji Ebe; Hidehisa Saeki; Takashi Sasaki; Tamotsu Ebihara; Masayuki Amagai; Satoshi Takeuchi; Masutaka Furue; Yusuke Nakamura; Mayumi Tamari
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-07
Journal Detail:
Title:  Nature genetics     Volume:  -     ISSN:  1546-1718     ISO Abbreviation:  Nat. Genet.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Laboratory for Respiratory Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan.
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