Document Detail


Genome-wide association studies in mice.
MedLine Citation:
PMID:  23044826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genome-wide association studies (GWASs) have transformed the field of human genetics and have led to the discovery of hundreds of genes that are implicated in human disease. The technological advances that drove this revolution are now poised to transform genetic studies in model organisms, including mice. However, the design of GWASs in mouse strains is fundamentally different from the design of human GWASs, creating new challenges and opportunities. This Review gives an overview of the novel study designs for mouse GWASs, which dramatically improve both the statistical power and resolution compared to classical gene-mapping approaches.
Authors:
Jonathan Flint; Eleazar Eskin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-10-09
Journal Detail:
Title:  Nature reviews. Genetics     Volume:  13     ISSN:  1471-0064     ISO Abbreviation:  Nat. Rev. Genet.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-18     Completed Date:  2013-01-04     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  100962779     Medline TA:  Nat Rev Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  807-17     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Breeding / methods*
Chromosome Mapping
Chromosomes, Mammalian / genetics*
Female
Genetic Predisposition to Disease / genetics*
Genome-Wide Association Study / methods*
Male
Mice
Research Design
Grant Support
ID/Acronym/Agency:
079912//Wellcome Trust; 090532//Wellcome Trust; K25 HL080079/HL/NHLBI NIH HHS; K25-HL080079/HL/NHLBI NIH HHS; N01-ES-45530/ES/NIEHS NIH HHS; P01 HL030568/HL/NHLBI NIH HHS; P01-HL28481/HL/NHLBI NIH HHS; P01-HL30568/HL/NHLBI NIH HHS; U01-DA024417/DA/NIDA NIH HHS; //Wellcome Trust
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