| Genome-wide association studies in mice. | |
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MedLine Citation:
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PMID: 23044826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genome-wide association studies (GWASs) have transformed the field of human genetics and have led to the discovery of hundreds of genes that are implicated in human disease. The technological advances that drove this revolution are now poised to transform genetic studies in model organisms, including mice. However, the design of GWASs in mouse strains is fundamentally different from the design of human GWASs, creating new challenges and opportunities. This Review gives an overview of the novel study designs for mouse GWASs, which dramatically improve both the statistical power and resolution compared to classical gene-mapping approaches. |
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Authors:
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Jonathan Flint; Eleazar Eskin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2012-10-09 |
Journal Detail:
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Title: Nature reviews. Genetics Volume: 13 ISSN: 1471-0064 ISO Abbreviation: Nat. Rev. Genet. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-18 Completed Date: 2013-01-04 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 100962779 Medline TA: Nat Rev Genet Country: England |
Other Details:
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Languages: eng Pagination: 807-17 Citation Subset: IM |
Affiliation:
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The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Breeding / methods* Chromosome Mapping Chromosomes, Mammalian / genetics* Female Genetic Predisposition to Disease / genetics* Genome-Wide Association Study / methods* Male Mice Research Design |
| Grant Support | |
ID/Acronym/Agency:
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K25 HL080079/HL/NHLBI NIH HHS; K25-HL080079/HL/NHLBI NIH HHS; N01-ES-45530/ES/NIEHS NIH HHS; P01 HL030568/HL/NHLBI NIH HHS; P01-HL28481/HL/NHLBI NIH HHS; P01-HL30568/HL/NHLBI NIH HHS; U01-DA024417/DA/NIDA NIH HHS; //Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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