Document Detail


Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
MedLine Citation:
PMID:  23143601     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P < 5 × 10(-6)) in an additional 1,099 cases and 2,913 controls. We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 × 10(-18)), 6q22.2 (rs9387478, P = 4.14 × 10(-10)) and 6p21.32 (rs2395185, P = 9.51 × 10(-9)). We also confirmed associations reported for loci at 5p15.33 and 3q28 and a recently reported finding at 17q24.3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking.
Authors:
Qing Lan; Chao A Hsiung; Keitaro Matsuo; Yun-Chul Hong; Adeline Seow; Zhaoming Wang; H Dean Hosgood; Kexin Chen; Jiu-Cun Wang; Nilanjan Chatterjee; Wei Hu; Maria Pik Wong; Wei Zheng; Neil Caporaso; Jae Yong Park; Chien-Jen Chen; Yeul Hong Kim; Young Tae Kim; Maria Teresa Landi; Hongbing Shen; Charles Lawrence; Laurie Burdett; Meredith Yeager; Jeffrey Yuenger; Kevin B Jacobs; I-Shou Chang; Tetsuya Mitsudomi; Hee Nam Kim; Gee-Chen Chang; Bryan A Bassig; Margaret Tucker; Fusheng Wei; Zhihua Yin; Chen Wu; She-Juan An; Biyun Qian; Victor Ho Fun Lee; Daru Lu; Jianjun Liu; Hyo-Sung Jeon; Chin-Fu Hsiao; Jae Sook Sung; Jin Hee Kim; Yu-Tang Gao; Ying-Huang Tsai; Yoo Jin Jung; Huan Guo; Zhibin Hu; Amy Hutchinson; Wen-Chang Wang; Robert Klein; Charles C Chung; In-Jae Oh; Kuan-Yu Chen; Sonja I Berndt; Xingzhou He; Wei Wu; Jiang Chang; Xu-Chao Zhang; Ming-Shyan Huang; Hong Zheng; Junwen Wang; Xueying Zhao; Yuqing Li; Jin Eun Choi; Wu-Chou Su; Kyong Hwa Park; Sook Whan Sung; Xiao-Ou Shu; Yuh-Min Chen; Li Liu; Chang Hyun Kang; Lingmin Hu; Chung-Hsing Chen; William Pao; Young-Chul Kim; Tsung-Ying Yang; Jun Xu; Peng Guan; Wen Tan; Jian Su; Chih-Liang Wang; Haixin Li; Alan Dart Loon Sihoe; Zhenhong Zhao; Ying Chen; Yi Young Choi; Jen-Yu Hung; Jun Suk Kim; Ho-Il Yoon; Qiuyin Cai; Chien-Chung Lin; In Kyu Park; Ping Xu; Jing Dong; Christopher Kim; Qincheng He; Reury-Perng Perng; Takashi Kohno; Sun-Seog Kweon; Chih-Yi Chen; Roel Vermeulen; Junjie Wu; Wei-Yen Lim; Kun-Chieh Chen; Wong-Ho Chow; Bu-Tian Ji; John K C Chan; Minjie Chu; Yao-Jen Li; Jun Yokota; Jihua Li; Hongyan Chen; Yong-Bing Xiang; Chong-Jen Yu; Hideo Kunitoh; Guoping Wu; Li Jin; Yen-Li Lo; Kouya Shiraishi; Ying-Hsiang Chen; Hsien-Chih Lin; Tangchun Wu; Yi-Long Wu; Pan-Chyr Yang; Baosen Zhou; Min-Ho Shin; Joseph F Fraumeni; Dongxin Lin; Stephen J Chanock; Nathaniel Rothman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2012-11-11
Journal Detail:
Title:  Nature genetics     Volume:  44     ISSN:  1546-1718     ISO Abbreviation:  Nat. Genet.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-29     Completed Date:  2013-02-13     Revised Date:  2013-05-13    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1330-5     Citation Subset:  IM    
Affiliation:
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / genetics*
Adult
Aged
Asian Continental Ancestry Group / genetics
Carcinoma, Squamous Cell / genetics*
Chromosomes, Human, Pair 10 / genetics
Chromosomes, Human, Pair 15 / genetics
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 5 / genetics
Chromosomes, Human, Pair 6 / genetics
Female
Genetic Loci*
Genetic Predisposition to Disease*
Genome-Wide Association Study*
Humans
Lung Neoplasms / genetics*
Middle Aged
Polymorphism, Single Nucleotide
Smoking
Grant Support
ID/Acronym/Agency:
N02 CP1101066/CP/NCI NIH HHS; R01-CA121210/CA/NCI NIH HHS; R37 CA070867/CA/NCI NIH HHS; R37 CA70867/CA/NCI NIH HHS

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