Document Detail


Genome-wide associatioin study of resistant starch (RS) phenotypes in a barley variety collection.
MedLine Citation:
PMID:  22998083     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Barley is primarily grown for feed and malt, but in some regions of the world it is also considered to be a staple food. Some barley types such as high-amylose barley have also gained importance as health-promoting foods. Starch that is not readily digested in the upper mammalian gastro-intestinal system, or resistant starch (RS), is considered to be valuable because it prevents some diet related diseases such as colon cancer. RS was quantified in a diverse collection of 209 spring barley varieties released in Europe during the last 100 years. The RS content varied from less than 1% to over 15% in the collection with 13 varieties having high RS content (above 11%) and 15 varieties below 1%. Combined with genome-wide association scanning (GWAS), SNP markers and candidate genes controlling the RS content in grains were identified. This identified 40 SNP markers with a LOD-score above 2, located on chromosome 2H, 3H, 5H and 6H, respectively. Among these SNPs, ten genes with a known role in starch biosynthesis were associated based on synteny conservation to the rice genome. The beta-glucan content was quantified in 61 varieties selected to represent extreme as well as medium RS values. The beta-glucan amount in the 15 varieties with RS < 1% ranged from 1.7 to 3.2%, from 1.76 to 2.54% in the 13 varieties with RS>11% and from 1.95 to 2.82% for those with 1%<RS<11%. No statistical significant correlation between RS content and beta-glucan content was found. This association genetic analysis of commercial varieties revealed a large variation in RS content and identified a number of SNP markers that can be explored for selection and further dissection of the pathway and control of RS phenotype.
Authors:
Xiaoli Shu; Gunter Backes; Soren K Rasmussen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-22
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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