| Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program. | |
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MedLine Citation:
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PMID: 22782721 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Neural development requires crosstalk between signaling pathways and chromatin. In this study, we demonstrate that neurogenesis is promoted by an interplay between the TGFβ pathway and the H3K27me3 histone demethylase (HDM) JMJD3. Genome-wide analysis showed that JMJD3 is targeted to gene promoters by Smad3 in neural stem cells (NSCs) and is essential to activate TGFβ-responsive genes. In vivo experiments in chick spinal cord revealed that the generation of neurons promoted by Smad3 is dependent on JMJD3 HDM activity. Overall, these findings indicate that JMJD3 function is required for the TGFβ developmental program to proceed. |
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Authors:
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Conchi Estarás; Naiara Akizu; Alejandra García; Sergi Beltrán; Xavier de la Cruz; Marian A Martínez-Balbás |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 139 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-07-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 2681-91 Citation Subset: IM |
Affiliation:
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Department of Molecular Genomics, Instituto de Biología Molecular de Barcelona (IBMB. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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