Document Detail


Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
MedLine Citation:
PMID:  25173106     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 × 10(-11) for rs2472493 near ABCA1 and P = 6.39 × 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10(-11) for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG.
Authors:
Pirro G Hysi; Ching-Yu Cheng; Henriët Springelkamp; Stuart Macgregor; Jessica N Cooke Bailey; Robert Wojciechowski; Veronique Vitart; Abhishek Nag; Alex W Hewitt; René Höhn; Cristina Venturini; Alireza Mirshahi; Wishal D Ramdas; Gudmar Thorleifsson; Eranga Vithana; Chiea-Chuen Khor; Arni B Stefansson; Jiemin Liao; Jonathan L Haines; Najaf Amin; Ya Xing Wang; Philipp S Wild; Ayse B Ozel; Jun Z Li; Brian W Fleck; Tanja Zeller; Sandra E Staffieri; Yik-Ying Teo; Gabriel Cuellar-Partida; Xiaoyan Luo; R Rand Allingham; Julia E Richards; Andrea Senft; Lennart C Karssen; Yingfeng Zheng; Céline Bellenguez; Liang Xu; Adriana I Iglesias; James F Wilson; Jae H Kang; Elisabeth M van Leeuwen; Vesteinn Jonsson; Unnur Thorsteinsdottir; Dominiek D G Despriet; Sarah Ennis; Sayoko E Moroi; Nicholas G Martin; Nomdo M Jansonius; Seyhan Yazar; E-Shyong Tai; Philippe Amouyel; James Kirwan; Leonieke M E van Koolwijk; Michael A Hauser; Fridbert Jonasson; Paul Leo; Stephanie J Loomis; Rhys Fogarty; Fernando Rivadeneira; Lisa Kearns; Karl J Lackner; Paulus T V M de Jong; Claire L Simpson; Craig E Pennell; Ben A Oostra; André G Uitterlinden; Seang-Mei Saw; Andrew J Lotery; Joan E Bailey-Wilson; Albert Hofman; Johannes R Vingerling; Cécilia Maubaret; Norbert Pfeiffer; Roger C W Wolfs; Hans G Lemij; Terri L Young; Louis R Pasquale; Cécile Delcourt; Timothy D Spector; Caroline C W Klaver; Kerrin S Small; Kathryn P Burdon; Kari Stefansson; Tien-Yin Wong; ; ; ; Ananth Viswanathan; David A Mackey; Jamie E Craig; Janey L Wiggs; Cornelia M van Duijn; Christopher J Hammond; Tin Aung
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-31
Journal Detail:
Title:  Nature genetics     Volume:  -     ISSN:  1546-1718     ISO Abbreviation:  Nat. Genet.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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