Document Detail


Genome-wide analysis of core cell cycle genes in the unicellular green alga Ostreococcus tauri.
MedLine Citation:
PMID:  15537805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cell cycle has been extensively studied in various organisms, and the recent access to an overwhelming amount of genomic data has given birth to a new integrated approach called comparative genomics. Comparing the cell cycle across species shows that its regulation is evolutionarily conserved; the best-known example is the pivotal role of cyclin-dependent kinases in all the eukaryotic lineages hitherto investigated. Interestingly, the molecular network associated with the activity of the CDK-cyclin complexes is also evolutionarily conserved, thus, defining a core cell cycle set of genes together with lineage-specific adaptations. In this paper, we describe the core cell cycle genes of Ostreococcus tauri, the smallest free-living eukaryotic cell having a minimal cellular organization with a nucleus, a single chloroplast, and only one mitochondrion. This unicellular marine green alga, which has diverged at the base of the green lineage, shows the minimal yet complete set of core cell cycle genes described to date. It has only one homolog of CDKA, CDKB, CDKD, cyclin A, cyclin B, cyclin D, cyclin H, Cks, Rb, E2F, DP, DEL, Cdc25, and Wee1. We have also added the APC and SCF E3 ligases to the core cell cycle gene set. We discuss the potential of genome-wide analysis in the identification of divergent orthologs of cell cycle genes in different lineages by mining the genomes of evolutionarily important and strategic organisms.
Authors:
Steven Robbens; Basheer Khadaroo; Alain Camasses; Evelyne Derelle; Conchita Ferraz; Dirk Inzé; Yves Van de Peer; Hervé Moreau
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-11-10
Journal Detail:
Title:  Molecular biology and evolution     Volume:  22     ISSN:  0737-4038     ISO Abbreviation:  Mol. Biol. Evol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-16     Completed Date:  2005-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501455     Medline TA:  Mol Biol Evol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  589-97     Citation Subset:  IM    
Affiliation:
Université Paris VI, Laboratoire Arago, Modèles en Biologie Cellulaire et Evolutive, Banyuls sur Mer, France.
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MeSH Terms
Descriptor/Qualifier:
Algae, Green / genetics*
Algal Proteins / genetics*
Cell Cycle / genetics*
Evolution, Molecular*
Genome*
Sequence Analysis, DNA*
Chemical
Reg. No./Substance:
0/Algal Proteins
Comments/Corrections
Erratum In:
Mol Biol Evol. 2005 Apr;22(4):1158

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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