| Genome-wide analysis of core cell cycle genes in Arabidopsis. | |
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MedLine Citation:
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PMID: 11971144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cyclin-dependent kinases and cyclins regulate with the help of different interacting proteins the progression through the eukaryotic cell cycle. A high-quality, homology-based annotation protocol was applied to determine the core cell cycle genes in the recently completed Arabidopsis genome sequence. In total, 61 genes were identified belonging to seven selected families of cell cycle regulators, for which 30 are new or corrections of the existing annotation. A new class of putative cell cycle regulators was found that probably are competitors of E2F/DP transcription factors, which mediate the G1-to-S progression. In addition, the existing nomenclature for cell cycle genes of Arabidopsis was updated, and the physical positions of all genes were compared with segmentally duplicated blocks in the genome, showing that 22 core cell cycle genes emerged through block duplications. This genome-wide analysis illustrates the complexity of the plant cell cycle machinery and provides a tool for elucidating the function of new family members in the future. |
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Authors:
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Klaas Vandepoele; Jeroen Raes; Lieven De Veylder; Pierre Rouzé; Stephane Rombauts; Dirk Inzé |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Plant cell Volume: 14 ISSN: 1040-4651 ISO Abbreviation: Plant Cell Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-23 Completed Date: 2002-07-23 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9208688 Medline TA: Plant Cell Country: United States |
Other Details:
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Languages: eng Pagination: 903-16 Citation Subset: IM |
Affiliation:
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Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Arabidopsis / enzymology, genetics* Carrier Proteins / genetics Cell Cycle Proteins / genetics* Cyclin-Dependent Kinases / genetics* Cyclins / genetics* Genome, Plant* Molecular Sequence Data Phylogeny Sequence Homology, Amino Acid Terminology as Topic |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Cell Cycle Proteins; 0/Cyclins; EC 2.7.11.22/Cyclin-Dependent Kinases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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