Document Detail

Genome sequence, comparative analysis, and population genetics of the domestic horse.
MedLine Citation:
PMID:  19892987     Owner:  NLM     Status:  MEDLINE    
We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.
C M Wade; E Giulotto; S Sigurdsson; M Zoli; S Gnerre; F Imsland; T L Lear; D L Adelson; E Bailey; R R Bellone; H Blöcker; O Distl; R C Edgar; M Garber; T Leeb; E Mauceli; J N MacLeod; M C T Penedo; J M Raison; T Sharpe; J Vogel; L Andersson; D F Antczak; T Biagi; M M Binns; B P Chowdhary; S J Coleman; G Della Valle; S Fryc; G Guérin; T Hasegawa; E W Hill; J Jurka; A Kiialainen; G Lindgren; J Liu; E Magnani; J R Mickelson; J Murray; S G Nergadze; R Onofrio; S Pedroni; M F Piras; T Raudsepp; M Rocchi; K H Røed; O A Ryder; S Searle; L Skow; J E Swinburne; A C Syvänen; T Tozaki; S J Valberg; M Vaudin; J R White; M C Zody; ; ; E S Lander; K Lindblad-Toh
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  326     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-06     Completed Date:  2009-12-02     Revised Date:  2013-12-24    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  865-7     Citation Subset:  IM    
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MeSH Terms
Animals, Domestic / genetics
Centromere / genetics
Chromosome Mapping
Chromosomes, Mammalian / genetics*
Computational Biology
DNA Copy Number Variations
Evolution, Molecular
Horses / genetics*
Molecular Sequence Data
Repetitive Sequences, Nucleic Acid
Sequence Analysis, DNA*
Grant Support
098051//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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