Document Detail

Genome-scale compositional comparisons in eukaryotes.
MedLine Citation:
PMID:  11282969     Owner:  NLM     Status:  MEDLINE    
We examined dinucleotide relative abundances and their biases in recent sequences of eukaryotic genomes and chromosomes, including human chromosomes 21 and 22, Saccharomyces cerevisiae, Arabidopsis thaliana, and Drosophila melanogaster. We found that dinucleotide relative abundances are remarkably constant across human chromosomes and within the DNA of a particular species. The dinucleotide biases differ between species, providing a genome signature that is characteristic of the bulk properties of an organism's DNA. We detail the relations between species genome signatures and suggest possible mechanisms for their origin and maintenance.
A J Gentles; S Karlin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Genome research     Volume:  11     ISSN:  1088-9051     ISO Abbreviation:  Genome Res.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-03     Completed Date:  2001-06-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9518021     Medline TA:  Genome Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  540-6     Citation Subset:  IM    
Mathematics Department, Stanford University, Stanford, California 94305, USA.
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MeSH Terms
Base Composition
Base Pairing
Caenorhabditis elegans / genetics
Dinucleotide Repeats / genetics*
Drosophila melanogaster / genetics
Eukaryotic Cells / chemistry*
Genes, Helminth / genetics*
Genes, Insect / genetics*
Genome, Fungal
Genome, Human
Genome, Protozoan
Leishmania major / genetics
Plasmodium falciparum / genetics
Saccharomyces cerevisiae / genetics
Species Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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