Document Detail


Genome reversion process of endopolyploidy confers chromosome instability on the descendent diploid cells.
MedLine Citation:
PMID:  21916845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endotetraploidy with 4-chromatid chromosomes divides by a bipolar, 2-step meiotic-like division back to diploidy (subcells), which is chiefly achieved by co-segregation of whole genomes uncoupled from spindle participation. This study shows diploid subcell inheritance of endopolyploid-division traits: perpendicular division relative to the cytoskeleton axis, dysfunctional centromere/kinetochore regions and whole genomic separations from co-segregation. The assimilation of these traits into the innate mitotic machinery of the subcells resulted in diploid mitotic divisions that tolerated mild disturbances in cycling progression and in chromosomal distributions. The data were interpreted as demonstrating a blending together of endopolyploid and mitotic division traits with result of an endo-modified mitosis in subcell propagation. Additionally, chromosomal stickiness caused breakage in anaphase/telophase. The observations are discussed in regard to a potential for slowly developing aneuploidy with increasing genomic complexity, which is widely accepted to be the basic route in tumorigenesis.
Authors:
Kirsten H Walen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell biology international     Volume:  36     ISSN:  1095-8355     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-06     Completed Date:  2012-04-25     Revised Date:  2012-08-02    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-45     Citation Subset:  IM    
Affiliation:
Viral and Rickettsial Disease Laboratory, California Department of Health Services, Richmond, 94804, USA. kwalen@dhs.ca.gov
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MeSH Terms
Descriptor/Qualifier:
Anaphase
Aneuploidy
Cell Line
Centromere
Chromosomal Instability*
Chromosome Segregation
Diploidy*
Genome, Human*
Humans
Mitotic Spindle Apparatus / metabolism
Telophase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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