| Genome-based expression profiles as a single standardized microarray platform for the diagnosis of experimental interstitial cystitis: an array of 75 genes model. | |
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MedLine Citation:
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PMID: 19153633 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION AND HYPOTHESIS: To investigate the molecular signature underlying experimental interstitial cystitis (IC) using cDNA microarray. METHODS: Microarray gene expression profiles are studied in bladder epithelium of C57BL/6 mice with ovalbumin or substance P-induced experimental IC versus Escherichia coli lipopolysaccharide-induced bacterial cystitis. RESULTS: Main findings are summarized as follows: firstly, a "75-gene" model was discovered to contain high expressions of bladder epithelium which feature in experimental IC. Secondly, glucose, lipid, nucleotide, xenobiotics, and amino acid metabolisms are involved in. Thirdly, T-cell-mediated immune and inflammatory responses are observed. Fourthly, Wnt, Tgf-beta, Mapk, and insulin growth factor receptor signaling pathways are also involved in. In addition, experimental IC leads to Ephrin- and Semaphorin-mediated axon guidance promoting parasympathetic inflammatory reflexes. CONCLUSIONS: Further characterization of human IC-induced gene expression profiles would enable the use of genome-based expression profiling for the therapeutic targets and diagnosis of IC. |
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Authors:
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Ling-Hong Tseng; Ilene Chen; Ming-Yang Chen; Chyi-Long Lee; Tsia-Shu Lo; L Keith Lloyd |
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Publication Detail:
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Type: Journal Article Date: 2009-01-20 |
Journal Detail:
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Title: International urogynecology journal and pelvic floor dysfunction Volume: 20 ISSN: - ISO Abbreviation: Int Urogynecol J Pelvic Floor Dysfunct Publication Date: 2009 May |
Date Detail:
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Created Date: 2012-08-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9514583 Medline TA: Int Urogynecol J Pelvic Floor Dysfunct Country: England |
Other Details:
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Languages: eng Pagination: 509-13 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and University of Chang Gung School of Medicine, Tao-Yuan, Taiwan, 3g7330@yahoo.com.tw. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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