Document Detail

Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.
MedLine Citation:
PMID:  22872573     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Genetic variation may influence chemotherapy response and overall survival in cancer patients.
EXPERIMENTAL DESIGN: We conducted a genome-wide scan in 535 advanced-stage non-small cell lung cancer (NSCLC) patients from two independent cohorts (307 from Nanjing and 228 from Beijing). A replication was carried out on an independent cohort of 340 patients from Southeastern China followed by a second validation on 409 patients from the Massachusetts General Hospital (Boston, MA).
RESULTS: Consistent associations with NSCLC survival were identified for five single-nucleotide polymorphisms (SNP) in Chinese populations with P values ranging from 3.63 × 10(-5) to 4.19 × 10(-7) in the additive genetic model. The minor allele of three SNPs (rs7629386 at 3p22.1, rs969088 at 5p14.1, and rs3850370 at 14q24.3) were associated with worse NSCLC survival while 2 (rs41997 at 7q31.31 and rs12000445 at 9p21.3) were associated with better NSCLC survival. In addition, rs7629386 at 3p22.1 (CTNNB1) and rs3850370 at 14q24.3 (SNW1-ALKBH1-NRXN3) were further replicated in the Caucasian population.
CONCLUSION: In this three-stage genome-wide association studies, we identified five SNPs as markers for survival of advanced-stage NSCLC patients treated with first-line platinum-based chemotherapy in Chinese Han populations. Two of these SNPs, rs7629386 and rs3850370, could also be markers for survival among Caucasian patients.
Lingmin Hu; Chen Wu; Xueying Zhao; Rebecca Heist; Li Su; Yang Zhao; Baohui Han; Songyu Cao; Minjie Chu; Juncheng Dai; Jing Dong; Yongqian Shu; Lin Xu; Yijiang Chen; Yi Wang; Feng Lu; Yue Jiang; Dianke Yu; Hongyan Chen; Wen Tan; Hongxia Ma; Jiaping Chen; Guangfu Jin; Tangchun Wu; Daru Lu; David C Christiani; Dongxin Lin; Zhibin Hu; Hongbing Shen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-07
Journal Detail:
Title:  Clinical cancer research : an official journal of the American Association for Cancer Research     Volume:  18     ISSN:  1078-0432     ISO Abbreviation:  Clin. Cancer Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-05-03     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9502500     Medline TA:  Clin Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5507-14     Citation Subset:  IM    
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MeSH Terms
Asian Continental Ancestry Group / genetics
Carboplatin / administration & dosage
Carcinoma, Non-Small-Cell Lung* / drug therapy,  genetics,  pathology
Cisplatin / administration & dosage
European Continental Ancestry Group / genetics
Genome-Wide Association Study*
Lung Neoplasms / drug therapy,  genetics
Middle Aged
Neoplasm Staging
Polymorphism, Single Nucleotide
Survival Analysis
beta Catenin / genetics*
Grant Support
CA092824-0/CA/NCI NIH HHS; R01 CA092824/CA/NCI NIH HHS; U19 CA148127/CA/NCI NIH HHS; U19-CA148127-01/CA/NCI NIH HHS
Reg. No./Substance:
0/CTNNB1 protein, human; 0/beta Catenin; BG3F62OND5/Carboplatin; Q20Q21Q62J/Cisplatin

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