Document Detail

A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol.
MedLine Citation:
PMID:  23031429     Owner:  NLM     Status:  Publisher    
Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10-8). We followed up the association in further genotyped monozygotic twins (N = 1,261), which showed a moderate association for the variant (P = 0.200, same direction of an effect). In addition, we report a new association on the level of apolipoprotein A-II (P = 4.03 × 10-8).
Ida Surakka; John B Whitfield; Markus Perola; Peter M Visscher; Grant W Montgomery; Mario Falchi; Gonneke Willemsen; Eco J C de Geus; Patrik K E Magnusson; Kaare Christensen; Thorkild I A Sørensen; Kirsi H Pietiläinen; Taina Rantanen; Kaisa Silander; Elisabeth Widén; Juha Muilu; Iffat Rahman; Ulrika Liljedahl; Ann-Christine Syvänen; Aarno Palotie; Jaakko Kaprio; Kirsten O Kyvik; Nancy L Pedersen; Dorret I Boomsma; Tim Spector; Nicholas G Martin; Samuli Ripatti; Leena Peltonen
Related Documents :
24657499 - Involvement of mitochondrial dysfunction and er-stress in the physiopathology of equine...
24001599 - Three snps in chromosome 11q23.3 are independently associated with systemic lupus eryth...
23202439 - Genome-wide scan for copy number variation association with age at onset of alzheimer's...
19158959 - Sequence alterations in rx in patients with microphthalmia, anophthalmia, and coloboma.
21253579 - Dissecting the within-africa ancestry of populations of african descent in the americas.
23300549 - A variant in the abo gene explains the variation in soluble e-selectin levels-results f...
19804059 - Scn5a-linked disease syndromes: complex monogenic disorders of cardiac rhythm.
25260809 - Factor v leiden 1691g/a and prothrombin gene 20210g/a polymorphisms as prothrombotic ma...
18793839 - Assessing the impact of composting and vermicomposting on bacterial community size and ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  -     ISSN:  1832-4274     ISO Abbreviation:  Twin Res Hum Genet     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-9     Citation Subset:  -    
FIMM, Institute for Molecular Medicine, Finland Biomedicum FI-00014, University of Helsinki, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cost-effectiveness of compression technologies for evidence-informed leg ulcer care: results from th...
Next Document:  Oxygen deficit and H2S in hemorrhagic shock in rat.