Document Detail


A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol.
MedLine Citation:
PMID:  23031429     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10-8). We followed up the association in further genotyped monozygotic twins (N = 1,261), which showed a moderate association for the variant (P = 0.200, same direction of an effect). In addition, we report a new association on the level of apolipoprotein A-II (P = 4.03 × 10-8).
Authors:
Ida Surakka; John B Whitfield; Markus Perola; Peter M Visscher; Grant W Montgomery; Mario Falchi; Gonneke Willemsen; Eco J C de Geus; Patrik K E Magnusson; Kaare Christensen; Thorkild I A Sørensen; Kirsi H Pietiläinen; Taina Rantanen; Kaisa Silander; Elisabeth Widén; Juha Muilu; Iffat Rahman; Ulrika Liljedahl; Ann-Christine Syvänen; Aarno Palotie; Jaakko Kaprio; Kirsten O Kyvik; Nancy L Pedersen; Dorret I Boomsma; Tim Spector; Nicholas G Martin; Samuli Ripatti; Leena Peltonen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  -     ISSN:  1832-4274     ISO Abbreviation:  Twin Res Hum Genet     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-9     Citation Subset:  -    
Affiliation:
FIMM, Institute for Molecular Medicine, Finland Biomedicum FI-00014, University of Helsinki, Finland.
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