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Genome-Wide Association Study for Intramuscular Fatty Acid Composition in an Iberian x Landrace Cross.
MedLine Citation:
PMID:  22785162     Owner:  NLM     Status:  Publisher    
The lipid content and fatty acid (FA) profile, have an important impact in human health, as well as in the technological transformation, nutritional and organoleptic quality of meat. A genome-wide association study (GWAS) on 144 backcross pigs (25% Iberian x 75% Landrace) was performed for 32 traits associated with intramuscular FA composition and indices of FA metabolism. The GWAS was carried out using Qxpak 5.0 and the genotyping information obtained from the Porcine SNP60K BeadChip. Signals of significant association considering a falsediscovery rate (q-value<0.05) were observed in fifteen of the 32 analyzed traits, and a total of 813 trait-associated SNPs (TAS), distributed in 43 chromosomal intervals on almost all autosomes, were annotated. According to the clustering analysis based on functional classification, several of the annotated genes are related to FA composition and lipid metabolism. Some interesting positional concordances among TAS and previously reported quantitative trait loci (QTL) for FA compositions and/or other lipid traits were also found. These common genomic regions for different traits suggest pleiotropic effects for FA composition, and were found primarily on SSC4, SSC8 and SSC16. These results contribute to our understanding of the complex genetic basis of FA composition and FA metabolism.
Y Ramayo-Caldas; A Mercadé; A Castelló; B Yang; C Rodríguez; E Alves; I Díaz; N Ibáñez-Escriche; J L Noguera; M Pérez-Enciso; A I Fernández; J M Folch
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-10
Journal Detail:
Title:  Journal of animal science     Volume:  -     ISSN:  1525-3163     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Centre for Research in Agricultural Genomics (CRAG), Consortium CSIC-IRTAUAB-UB. Edifici CRAG, Campus Universitat Autonoma Barcelona. 08193 Bellaterra, Spain.
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