| A genome-wide association study of BMI in American Indians. | |
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MedLine Citation:
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PMID: 21701565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous studies have been done to understand genetic contributors to BMI, but only a limited number of studies have been done in nonwhite groups such as American Indians. A genome-wide association study (GWAS) for BMI was therefore performed in Pima Indians. BMI measurements from a longitudinal study of 1,120 Pima Indians and 454,194 single-nucleotide polymorphisms (SNPs) from the 1 million Affymetrix SNP panel were used (35% of SNPs were excluded due to minor allele frequency <0.05). Data included BMI measured at multiple examinations collected from 1965 to 2004, as well as the maximum BMI at one of these visits. General and within-family tests were performed using a maximum-likelihood based mixed model procedure. No SNP reached a genome-wide significance level (estimated at P < 4.94 × 10(-7)). For repeated measures analyses, the strongest associations for general and within-family tests mapped to two different regions on chromosome 6 (rs9342220 (P = 1.39 × 10(-6)) and rs7758764 (P = 2.51 × 10(-6)), respectively). For maximum BMI, the strongest association for the general tests mapped to chromosome 4 (rs17612333; P = 1.98 × 10(-6)) and to chromosome 3 (rs11127958; P = 1.53 × 10(-6)) for the within-family tests. Further analysis is important because only a few of these regions have been previously implicated in a GWAS and genetic susceptibility may differ by ethnicity. |
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Authors:
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Alka Malhotra; Sayuko Kobes; William C Knowler; Leslie J Baier; Clifton Bogardus; Robert L Hanson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2011-06-23 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 19 ISSN: 1930-739X ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-28 Completed Date: 2012-03-27 Revised Date: 2012-08-13 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 2102-6 Citation Subset: IM |
Affiliation:
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Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA. alka@niddk.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Body Mass Index* Chromosomes, Human* Cohort Studies Family Female Gene Frequency Genetic Predisposition to Disease Genome, Human* Genome-Wide Association Study / methods Genotype Humans Indians, North American / genetics* Longitudinal Studies Male Middle Aged Models, Genetic Obesity / ethnology*, genetics* Polymorphism, Single Nucleotide* Young Adult |
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