Document Detail


A genome-wide association study of BMI in American Indians.
MedLine Citation:
PMID:  21701565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Numerous studies have been done to understand genetic contributors to BMI, but only a limited number of studies have been done in nonwhite groups such as American Indians. A genome-wide association study (GWAS) for BMI was therefore performed in Pima Indians. BMI measurements from a longitudinal study of 1,120 Pima Indians and 454,194 single-nucleotide polymorphisms (SNPs) from the 1 million Affymetrix SNP panel were used (35% of SNPs were excluded due to minor allele frequency <0.05). Data included BMI measured at multiple examinations collected from 1965 to 2004, as well as the maximum BMI at one of these visits. General and within-family tests were performed using a maximum-likelihood based mixed model procedure. No SNP reached a genome-wide significance level (estimated at P < 4.94 × 10(-7)). For repeated measures analyses, the strongest associations for general and within-family tests mapped to two different regions on chromosome 6 (rs9342220 (P = 1.39 × 10(-6)) and rs7758764 (P = 2.51 × 10(-6)), respectively). For maximum BMI, the strongest association for the general tests mapped to chromosome 4 (rs17612333; P = 1.98 × 10(-6)) and to chromosome 3 (rs11127958; P = 1.53 × 10(-6)) for the within-family tests. Further analysis is important because only a few of these regions have been previously implicated in a GWAS and genetic susceptibility may differ by ethnicity.
Authors:
Alka Malhotra; Sayuko Kobes; William C Knowler; Leslie J Baier; Clifton Bogardus; Robert L Hanson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2011-06-23
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  19     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-28     Completed Date:  2012-03-27     Revised Date:  2012-08-13    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2102-6     Citation Subset:  IM    
Affiliation:
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA. alka@niddk.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Body Mass Index*
Chromosomes, Human*
Cohort Studies
Family
Female
Gene Frequency
Genetic Predisposition to Disease
Genome, Human*
Genome-Wide Association Study / methods
Genotype
Humans
Indians, North American / genetics*
Longitudinal Studies
Male
Middle Aged
Models, Genetic
Obesity / ethnology*,  genetics*
Polymorphism, Single Nucleotide*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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