| Genome-wide association studies will unlock the genetic basis of hypertension: pro side of the argument. | |
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MedLine Citation:
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PMID: 21060004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This brief commentary is based on the debate that took part in May 2010 in New York. We describe the initial difficulties experienced in early genome-wide association studies of blood pressure and hypertension, as well as strategic developments, including large meta-analyses and sampling from the extremes of blood pressure distribution. The reasons for negative attitudes toward the genome-wide association studies include their nonhypothesis-driven character and the need for very large sample sizes. Nevertheless, we describe published successes, which include 13 single nucleotide polymorphisms/loci associated with blood pressure and hypertension at P < 5 x 10⁻⁸, which fulfill the criteria of genome-wide significance. We conclude by suggesting a way forward, which will include resequencing to aid fine mapping and the identification of causal variants, even bigger meta-analyses, and, most importantly, appropriate functional studies leading to clinically useful applications. |
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Authors:
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Anna F Dominiczak; Patricia B Munroe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 56 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-02 Completed Date: 2010-12-17 Revised Date: 2011-02-10 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 1017-1020; discussion 1025 Citation Subset: IM |
Affiliation:
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Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, UK. ad7e@clinmed.gla.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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genetics Chromosome Mapping Genetic Loci Genome-Wide Association Study* Humans Hypertension / epidemiology, genetics* Meta-Analysis as Topic Polymorphism, Single Nucleotide Sample Size |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation; //Medical Research Council; //Wellcome Trust |
| Comments/Corrections | |
Comment In:
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Hypertension. 2010 Dec;56(6):1021-5
[PMID:
21060005
]
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Erratum In:
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Hypertension. 2011 Feb;57(2):e8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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