| Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. | |
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MedLine Citation:
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PMID: 21873549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis. |
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Authors:
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Rona J Strawbridge; Josée Dupuis; Inga Prokopenko; Adam Barker; Emma Ahlqvist; Denis Rybin; John R Petrie; Mary E Travers; Nabila Bouatia-Naji; Antigone S Dimas; Alexandra Nica; Eleanor Wheeler; Han Chen; Benjamin F Voight; Jalal Taneera; Stavroula Kanoni; John F Peden; Fabiola Turrini; Stefan Gustafsson; Carina Zabena; Peter Almgren; David J P Barker; Daniel Barnes; Elaine M Dennison; Johan G Eriksson; Per Eriksson; Elodie Eury; Lasse Folkersen; Caroline S Fox; Timothy M Frayling; Anuj Goel; Harvest F Gu; Momoko Horikoshi; Bo Isomaa; Anne U Jackson; Karen A Jameson; Eero Kajantie; Julie Kerr-Conte; Teemu Kuulasmaa; Johanna Kuusisto; Ruth J F Loos; Jian'an Luan; Konstantinos Makrilakis; Alisa K Manning; María Teresa Martínez-Larrad; Narisu Narisu; Maria Nastase Mannila; John Ohrvik; Clive Osmond; Laura Pascoe; Felicity Payne; Avan A Sayer; Bengt Sennblad; Angela Silveira; Alena Stancáková; Kathy Stirrups; Amy J Swift; Ann-Christine Syvänen; Tiinamaija Tuomi; Ferdinand M van 't Hooft; Mark Walker; Michael N Weedon; Weijia Xie; Björn Zethelius; ; ; ; ; ; Halit Ongen; Anders Mälarstig; Jemma C Hopewell; Danish Saleheen; John Chambers; Sarah Parish; John Danesh; Jaspal Kooner; Claes-Göran Ostenson; Lars Lind; Cyrus C Cooper; Manuel Serrano-Ríos; Ele Ferrannini; Tom J Forsen; Robert Clarke; Maria Grazia Franzosi; Udo Seedorf; Hugh Watkins; Philippe Froguel; Paul Johnson; Panos Deloukas; Francis S Collins; Markku Laakso; Emmanouil T Dermitzakis; Michael Boehnke; Mark I McCarthy; Nicholas J Wareham; Leif Groop; François Pattou; Anna L Gloyn; George V Dedoussis; Valeriya Lyssenko; James B Meigs; Inês Barroso; Richard M Watanabe; Erik Ingelsson; Claudia Langenberg; Anders Hamsten; Jose C Florez |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-08-26 |
Journal Detail:
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Title: Diabetes Volume: 60 ISSN: 1939-327X ISO Abbreviation: Diabetes Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-28 Completed Date: 2011-11-28 Revised Date: 2012-05-23 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: United States |
Other Details:
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Languages: eng Pagination: 2624-34 Citation Subset: AIM; IM |
Affiliation:
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Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Diabetes Mellitus, Type 2 / blood, genetics*, metabolism Fasting / blood* Female Genetic Variation Genome, Human* Genotype Humans Insulin / blood Male Polymorphism, Single Nucleotide / genetics* Proinsulin / blood* |
| Grant Support | |
ID/Acronym/Agency:
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077016/Z/05/Z//Wellcome Trust; 083270/Z/07/Z//Wellcome Trust; 81696//Medical Research Council; DK062370/DK/NIDDK NIH HHS; G0601261//Medical Research Council; G0700222(81696)//Medical Research Council; K24 DK080140/DK/NIDDK NIH HHS; R01 DK078616/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Insulin; 9035-68-1/Proinsulin |
| Investigator | |
Investigator/Affiliation:
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Benjamin F Voight / ; Laura J Scott / ; Valgerdur Steinthorsdottir / ; Andrew P Morris / ; Christian Dina / ; Ryan P Welch / ; Eleftheria Zeggini / ; Cornelia Huth / ; Yurii S Aulchenko / ; Gudmar Thorleifsson / ; Laura J Mcculloch / ; Teresa Ferreira / ; Harald Grallert / ; Najaf Amin / ; Guanming Wu / ; Cristen J Willer / ; Soumya Raychaudhuri / ; Steve A Mccarroll / ; Claudia Langenberg / ; Oliver M Hofmann / ; Lu Qi / ; Ayellet V Segrè / ; Mandy van Hoek / ; Pau Navarro / ; Kristin Ardlie / ; Beverley Balkau / ; Rafn Benediktsson / ; Amanda J Bennett / ; Roza Blagieva / ; Eric Boerwinkle / ; Lori L Bonnycastle / ; Kristina Bengtsson Boström / ; Bert Bravenboer / ; Suzannah Bumpstead / ; P Burtt / ; Guillaume Charpentier / ; Peter S Chines / ; Marilyn Cornelis / ; David J Couper / ; Gabe Crawford / ; Alex S F Doney / ; Katherine S Elliott / ; Amanda L Elliott / ; Michael R Erdos / ; Caroline S Fox / ; Christopher S Franklin / ; Christian Gieger / ; Niels Grarup / ; Todd Green / ; Simon Griffin / ; Christopher J Groves / ; Candace Guiducci / ; Samy Hadjadj / ; Neelam Hassanali / ; Christian Herder / ; Bo Isomaa / ; Anne U Jackson / ; Paul R V Johnson / ; Torben Jørgensen / ; Wen H L Kao / ; Norman Klopp / ; Augustine Kong / ; Peter Kraft / ; Johanna Kuusisto / ; Torsten Lauritzen / ; Man Li / ; Aloysius Lieverse / ; Cecilia M Lindgren / ; Valeriya Lyssenko / ; Michel Marre / ; Thomas Meitinger / ; Kristian Midthjell / ; Mario A Morken / ; Narisu Narisu / ; Peter Nilsson / ; Katharine R Owen / ; Felicity Payne / ; John R B Perry / ; Kristin Petersen / ; Carl Platou / ; Christine Proença / ; Inga Prokopenko / ; Wolfgang Rathmann / ; N William Rayner / ; Neil R Robertson / ; Ghislain Rocheleau / ; Michael Roden / ; Michael J Sampson / ; Richa Saxena / ; Beverley M Shields / ; Peter Shrader / ; Gunnar Sigurdsson / ; Thomas Sparsø / ; Klaus Strassburger / ; Heather M Stringham / ; Qi Sun / ; Amy J Swift / ; Barbara Thorand / ; Jean Tichet / ; Tiinamaija Tuomi / ; Rob M van Dam / ; Timon W van Haeften / ; Thijs van Herpt / ; Jana V van Vliet / ; G Bragi Walters / ; Michael N Weedon / ; Cisca Wijmenga / ; Jacqueline Witteman / ; Richard N Bergman / ; Stephane Cauchi / ; Francis S Collins / ; Anna L Gloyn / ; Ulf Gyllensten / ; Torben Hansen / ; Winston A Hide / ; Graham A Hitman / ; Albert Hofman / ; David J Hunter / ; Kristian Hveem / ; Markku Laakso / ; Karen L Mohlke / ; Andrew D Morris / ; Colin N A Palmer / ; Peter P Pramstaller / ; Igor Rudan / ; Eric Sijbrands / ; Lincoln D Stein / ; Jaakko Tuomilehto / ; Andre Uitterlinden / ; Mark Walker / ; Nicholas J Wareham / ; Richard M Watanabe / ; Gonçalo R Abecasis / ; Bernhard O Boehm / ; Harry Campbell / ; Mark J Daly / ; Andrew T Hattersley / ; Frank B Hu / ; James B Meigs / ; James S Pankow / ; Oluf Pedersen / ; Erich Wichmann / ; Inês Barroso / ; Jose C Florez / ; Timothy M Frayling / ; Leif Groop / ; Rob Sladek / ; Unnur Thorsteinsdottir / ; James F Wilson / ; Thomas Illig / ; Philippe Froguel / ; Kari Stefansson / ; David Altshuler / ; Michael Boehnke / ; Mark I McCarthy / ; Elizabeth K Speliotes / ; Cristen J Willer / ; Sonja I Berndt / ; Keri L Monda / ; Gudmar Thorleifsson / ; Anne U Jackson / ; Hana Lango Allen / ; Cecilia M Lindgren / ; Jian'an Luan / ; Reedik Mägi / ; Joshua C Randall / ; Sailaja Vedantam / ; Thomas W Winkler / ; Lu Qi / ; Tsegaselassie Workalemahu / ; Iris M Heid / ; Valgerdur Steinthorsdottir / ; Heather M Stringham / ; Michael N Weedon / ; Eleanor Wheeler / ; Andrew R Wood / ; Teresa Ferreira / ; Robert J Weyant / ; Ayellet V Segrè / ; Karol Estrada / ; Liming Liang / ; James Nemesh / ; Ju-Hyun Park / ; Stefan Gustafsson / ; Tuomas O Kilpeläinen / ; Jian Yang / ; Nabila Bouatia-Naji / ; Tõnu Esko / ; Mary F Feitosa / ; Zoltán Kutalik / ; Massimo Mangino / ; Soumya Raychaudhuri / ; Andre Scherag / ; Albert Vernon Smith / ; Ryan Welch / ; Jing Hua Zhao / ; Katja K Aben / ; Devin M Absher / ; Najaf Amin / ; Anna L Dixon / ; Eva Fisher / ; Nicole L Glazer / ; Michael E Goddard / ; Nancy L Heard-Costa / ; Volker Hoesel / ; Jouke-Jan Hottenga / ; Åsa Johansson / ; Toby Johnson / ; Shamika Ketkar / ; Claudia Lamina / ; Shengxu Li / ; Miriam F Moffatt / ; Richard H Myers / ; Narisu Narisu / ; John R B Perry / ; Marjolein J Peters / ; Michael Preuss / ; Samuli Ripatti / ; Fernando Rivadeneira / ; Camilla Sandholt / ; Laura J Scott / ; Nicholas J Timpson / ; Jonathan P Tyrer / ; Sophie van Wingerden / ; Richard M Watanabe / ; Charles C White / ; Fredrik Wiklund / ; Christina Barlassina / ; Daniel I Chasman / ; Matthew N Cooper / ; John-Olov Jansson / ; Robert W Lawrence / ; Niina Pellikka / ; Inga Prokopenko / ; Jianxin Shi / ; Elisabeth Thiering / ; Helene Alavere / ; Maria T S Alibrandi / ; Peter Almgren / ; Alice M Arnold / ; Thor Aspelund / ; Larry D Atwood / ; Beverley Balkau / ; Anthony J Balmforth / ; Amanda J Bennett / ; Yoav Ben-Shlomo / ; Richard N Bergman / ; Sven Bergmann / ; Heike Biebermann / ; Alexandra I F Blakemore / ; Tanja Boes / ; Lori L Bonnycastle / ; Stefan R Bornstein / ; Morris J Brown / ; Thomas A Buchanan / ; Fabio Busonero / ; Harry Campbell / ; Francesco P Cappuccio / ; Christine Cavalcanti-Proença / ; Yii-Der Ida Chen / ; Chih-Mei Chen / ; Peter S Chines / ; Robert Clarke / ; Lachlan Coin / ; John Connell / ; Ian N M Day / ; Martin den Heijer / ; Jubao Duan / ; Shah Ebrahim / ; Paul Elliott / ; Roberto Elosua / ; Gudny Eiriksdottir / ; Michael R Erdos / ; Johan G Eriksson / ; Maurizio F Facheris / ; Stephan B Felix / ; Pamela Fischer-Posovszky / ; Aaron R Folsom / ; Nele Friedrich / ; Nelson B Freimer / ; Mao Fu / ; Stefan Gaget / ; Pablo V Gejman / ; Eco J C Geus / ; Christian Gieger / ; Anette P Gjesing / ; Anuj Goel / ; Philippe Goyette / ; Harald Grallert / ; Jürgen Grässler / ; Danielle M Greenawalt / ; Christopher J Groves / ; Vilmundur Gudnason / ; Candace Guiducci / ; Anna-Liisa Hartikainen / ; Neelam Hassanali / ; Alistair S Hall / ; Aki S Havulinna / ; Caroline Hayward / ; Andrew C Heath / ; Christian Hengstenberg / ; Andrew A Hicks / ; Anke Hinney / ; Albert Hofman / ; Georg Homuth / ; Jennie Hui / ; Wilmar Igl / ; Carlos Iribarren / ; Bo Isomaa / ; Kevin B Jacobs / ; Ivonne Jarick / ; Elizabeth Jewell / ; Ulrich John / ; Torben Jørgensen / ; Pekka Jousilahti / ; Antti Jula / ; Marika Kaakinen / ; Eero Kajantie / ; Lee M Kaplan / ; Sekar Kathiresan / ; Johannes Kettunen / ; Leena Kinnunen / ; Joshua W Knowles / ; Ivana Kolcic / ; Inke R König / ; Seppo Koskinen / ; Peter Kovacs / ; Johanna Kuusisto / ; Peter Kraft / ; Kirsti Kvaløy / ; Jaana Laitinen / ; Olivier Lantieri / ; Chiara Lanzani / ; Lenore J Launer / ; Cecile Lecoeur / ; Lehtimäki Terho / ; Guillaume Lettre / ; Jianjun Liu / ; Marja-Liisa Lokki / ; Mattias Lorentzon / ; Robert N Luben / ; Barbara Ludwig / ; MAGIC / ; Paolo Manunta / ; Diana Marek / ; Michel Marre / ; Nicholas G Martin / ; Wendy L McArdle / ; Anne McCarthy / ; Barbara McKnight / ; Thomas Meitinger / ; Olle Melander / ; David Meyre / ; Kristian Midthjell / ; Grant W Montgomery / ; Mario A Morken / ; Andrew P Morris / ; Rosanda Mulic / ; Julius S Ngwa / ; Mari Nelis / ; Matt J Neville / ; Dale R Nyholt / ; Christopher J O'Donnell / ; Stephen O'Rahilly / ; Ken K Ong / ; Ben Oostra / ; Guillaume Paré / ; Alex N Parker / ; Markus Perola / ; Irene Pichler / ; Kirsi H Pietiläinen / ; Carl G P Platou / ; Ozren Polasek / ; Anneli Pouta / ; Suzanne Rafelt / ; Olli Raitakari / ; Nigel W Rayner / ; Martin Ridderstråle / ; Winfried Rief / ; Aimo Ruokonen / ; Neil R Robertson / ; Peter Rzehak / ; Veikko Salomaa / ; Alan R Sanders / ; Manjinder S Sandhu / ; Serena Sanna / ; Jouko Saramies / ; Markku J Savolainen / ; Susann Scherag / ; Sabine Schipf / ; Stefan Schreiber / ; Heribert Schunkert / ; Kaisa Silander / ; Juha Sinisalo / ; David S Siscovick / ; Jan H Smit / ; Nicole Soranzo / ; Ulla Sovio / ; Jonathan Stephens / ; Ida Surakka / ; Amy J Swift / ; Mari-Liis Tammesoo / ; Jean-Claude Tardif / ; Maris Teder-Laving / ; Tanya M Teslovich / ; John R Thompson / ; Brian Thomson / ; Anke Tönjes / ; Tiinamaija Tuomi / ; Joyce B J van Meurs / ; Gert-Jan van Ommen / ; Vincent Vatin / ; Jorma Viikari / ; Sophie Visvikis-Siest / ; Veronique Vitart / ; Carla I G Vogel / ; Benjamin F Voight / ; Lindsay L Waite / ; Henri Wallaschofski / ; G Bragi Walters / ; Elisabeth Widen / ; Susanna Wiegand / ; Sarah H Wild / ; Gonneke Willemsen / ; Daniel R Witte / ; Jacqueline C Witteman / ; Jianfeng Xu / ; Qunyuan Zhang / ; Lina Zgaga / ; Andreas Ziegler / ; Paavo Zitting / ; John P Beilby / ; I Sadaf Farooqi / ; Johannes Hebebrand / ; Heikki V Huikuri / ; Alan L James / ; Mika Kähönen / ; Douglas F Levinson / ; Fabio Macciardi / ; Markku S Nieminen / ; Claes Ohlsson / ; Lyle J Palmer / ; Paul M Ridker / ; Michael Stumvoll / ; Jacques S Beckmann / ; Heiner Boeing / ; Eric Boerwinkle / ; Boomsma Dorret I / ; Mark J Caulfield / ; Stephen J Chanock / ; Francis S Collins / ; L Adrienne Cupples / ; George Davey Smith / ; Jeanette Erdmann / ; Philippe Froguel / ; Henrik Grönberg / ; Ulf Gyllensten / ; Per Hall / ; Torben Hansen / ; Tamara B Harris / ; Andrew T Hattersley / ; Richard B Hayes / ; Joachim Heinrich / ; Frank B Hu / ; Kristian Hveem / ; Thomas Illig / ; Marjo-Riitta Jarvelin / ; Jaakko Kaprio / ; Fredrik Karpe / ; Kay Tee Khaw / ; Lambertus A Kiemeney / ; Heiko Krude / ; Markku Laakso / ; Debbie A Lawlor / ; Andres Metspalu / ; Patricia B Munroe / ; Willem H Ouwehand / ; Oluf Pedersen / ; Brenda W Penninx / ; Annette Peters / ; Peter P Pramstaller / ; Thomas Quertermous / ; Thomas Reinehr / ; Aila Rissanen / ; Igor Rudan / ; Nilesh J Samani / ; Peter E H Schwarz / ; Alan R Shuldiner / ; Timothy D Spector / ; Jaakko Tuomilehto / ; Manuela Uda / ; André Uitterlinden / ; Timo T Valle / ; Martin Wabitsch / ; Gérard Waeber / ; Nicholas J Wareham / ; Hugh Watkins / ; Steven A McCarroll / ; Purcell Shaun / ; Schadt Eric E / ; Visscher Peter M / ; Themistocles L Assimes / ; Ingrid B Borecki / ; Panos Deloukas / ; Caroline S Fox / ; Leif C Groop / ; Talin Haritunians / ; David J Hunter / ; Robert C Kaplan / ; Karen L Mohlke / ; Jeffrey R O'Connell / ; Leena Peltonen / ; David Schlessinger / ; David P Strachan / ; Cornelia M van Duijn / ; H Barroso / ; Michael Boehnke / ; Kari Stefansson / ; Kari E North / ; Mark I McCarthy / ; Joel N Hirschhorn / ; Erik Ingelsson / ; Ruth J F Loos / ; Alexandra C Nica / ; Leopold Parts / ; Daniel Glass / ; James Nisbet / ; Amy Barrett / ; Magdalena Sekowska / ; Mary Travers / ; Simon Potter / ; Elin Grundberg / ; Kerrin Small / ; Åsa K Hedman / ; Veronique Bataille / ; Jordana Tzenova Bell / ; Gabriela Surdulescu / ; Antigone S Dimas / ; Catherine Ingle / ; Frank O Nestle / ; Paola di Meglio / ; Josine L Min / ; Alicja Wilk / ; Christopher J Hammond / ; Neelam Hassanali / ; Tsun-Po Yang / ; Stephen B Montgomery / ; Steve O'Rahilly / ; Cecilia M Lindgren / ; Krina T Zondervan / ; Nicole Soranzo / ; Inês Barroso / ; Richard Durbin / ; Kourosh Ahmadi / ; Panos Deloukas / ; Mark I McCarthy / ; Emmanouil T Dermitzakis / ; Timothy D Spector / ; Heribert Schunkert / ; Inke R König / ; Sekar Kathiresan / ; Muredach P Reilly / ; Themistocles L Assimes / ; Hilma Holm / ; Michael Preuss / ; Alexandre F R Stewart / ; Maja Barbalic / ; Christian Gieger / ; Devin Absher / ; Zouhair Aherrahrou / ; Hooman Allayee / ; David Altshuler / ; Sonia S Anand / ; Karl Andersen / ; Jeffrey L Anderson / ; Diego Ardissino / ; Stephen G Ball / ; Anthony J Balmforth / ; Timothy A Barnes / ; Diane M Becker / ; Lewis C Becker / ; Klaus Berger / ; Joshua C Bis / ; S Matthijs Boekholdt / ; Eric Boerwinkle / ; Peter S Braund / ; Morris J Brown / ; Mary Susan Burnett / ; Ian Buysschaert / ; Cardiogenics / ; John F Carlquist / ; Li Chen / ; Sven Cichon / ; Veryan Codd / ; Robert W Davies / ; George Dedoussis / ; Abbas Dehghan / ; Serkalem Demissie / ; Joseph M Devaney / ; Patrick Diemert / ; Ron Do / ; Angela Doering / ; Sandra Eifert / ; Nour Eddine El Mokhtari / ; Stephen G Ellis / ; Roberto Elosua / ; James C Engert / ; Stephen E Epstein / ; Ulf de Faire / ; Marcus Fischer / ; Aaron R Folsom / ; Jennifer Freyer / ; Bruna Gigante / ; Domenico Girelli / ; Solveig Gretarsdottir / ; Vilmundur Gudnason / ; Jeffrey R Gulcher / ; Eran Halperin / ; Naomi Hammond / ; Stanley L Hazen / ; Albert Hofman / ; Benjamin D Horne / ; Thomas Illig / ; Carlos Iribarren / ; Gregory T Jones / ; J Wouter Jukema / ; Michael A Kaiser / ; Lee M Kaplan / ; John J P Kastelein / ; Kay-Tee Khaw / ; Joshua W Knowles / ; Genovefa Kolovou / ; Augustine Kong / ; Reijo Laaksonen / ; Diether Lambrechts / ; Karin Leander / ; Guillaume Lettre / ; Mingyao Li / ; Wolfgang Lieb / ; Christina Loley / ; Andrew J Lotery / ; Pier M Mannucci / ; Seraya Maouche / ; Nicola Martinelli / ; Pascal P McKeown / ; Christa Meisinger / ; Thomas Meitinger / ; Olle Melander / ; Pier Angelica Merlini / ; Vincent Mooser / ; Thomas Morgan / ; Thomas W Mühleisen / ; Joseph B Muhlestein / ; Thomas Münzel / ; Kiran Musunuru / ; Janja Nahrstaedt / ; Christopher P Nelson / ; Markus M Nöthen / ; Oliviero Olivieri / ; Riyaz S Patel / ; Chris C Patterson / ; Annette Peters / ; Flora Peyvandi / ; Liming Qu / ; Arshed A Quyyumi / ; Daniel J Rader / ; Loukianos S Rallidis / ; Catherine Rice / ; Frits R Rosendaal / ; Diana Rubin / ; Veikko Salomaa / ; M Lourdes Sampietro / ; Manj S Sandhu / ; Eric Schadt / ; Arne Schäfer / ; Arne Schillert / ; Stefan Schreiber / ; Jürgen Schrezenmeir / ; Stephen M Schwartz / ; David S Siscovick / ; Mohan Sivananthan / ; Suthesh Sivapalaratnam / ; Albert Smith / ; Tamara B Smith / ; Jaapjan D Snoep / ; Nicole Soranzo / ; John A Spertus / ; Klaus Stark / ; Kathy Stirrups / ; Monika Stoll / ; W H Wilson Tang / ; Stephanie Tennstedt / ; Gudmundur Thorgeirsson / ; Gudmar Thorleifsson / ; Maciej Tomaszewski / ; Andre G Uitterlinden / ; Andre M van Rij / ; Benjamin F Voight / ; Nick J Wareham / ; George A Wells / ; H-Erich Wichmann / ; Philipp S Wild / ; Christina Willenborg / ; Jaqueline C M Witteman / ; Benjamin J Wright / ; Shu Ye / ; Tanja Zeller / ; Andreas Ziegler / ; Francois Cambien / ; Alison H Goodall / ; L Adrienne Cupples / ; Thomas Quertermous / ; Winfried März / ; Christian Hengstenberg / ; Stefan Blankenberg / ; Willem H Ouwehand / ; Alistair S Hall / ; Panos Deloukas / ; John R Thompson / ; Kari Stefansson / ; Robert Roberts / ; Unnur Thorsteinsdottir / ; Christopher J O'Donnell / ; Ruth McPherson / ; Jeanette Erdmann / ; Samani Nilesh J / |
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