| Genome regulation by long noncoding RNAs. | |
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MedLine Citation:
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PMID: 22663078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The central dogma of gene expression is that DNA is transcribed into messenger RNAs, which in turn serve as the template for protein synthesis. The discovery of extensive transcription of large RNA transcripts that do not code for proteins, termed long noncoding RNAs (lncRNAs), provides an important new perspective on the centrality of RNA in gene regulation. Here, we discuss genome-scale strategies to discover and characterize lncRNAs. An emerging theme from multiple model systems is that lncRNAs form extensive networks of ribonucleoprotein (RNP) complexes with numerous chromatin regulators and then target these enzymatic activities to appropriate locations in the genome. Consistent with this notion, lncRNAs can function as modular scaffolds to specify higher-order organization in RNP complexes and in chromatin states. The importance of these modes of regulation is underscored by the newly recognized roles of long RNAs for proper gene control across all kingdoms of life. |
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Authors:
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John L Rinn; Howard Y Chang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annual review of biochemistry Volume: 81 ISSN: 1545-4509 ISO Abbreviation: Annu. Rev. Biochem. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-06-05 Completed Date: 2012-08-21 Revised Date: 2013-03-27 |
Medline Journal Info:
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Nlm Unique ID: 2985150R Medline TA: Annu Rev Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 145-66 Citation Subset: IM |
Affiliation:
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Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA. john_rinn@harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease / genetics Gene Expression Regulation* Genome, Human Genome-Wide Association Study Humans RNA, Untranslated / metabolism* Ribonucleoproteins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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1DP2OD00667-01/OD/NIH HHS; 1P01GM099117-01/GM/NIGMS NIH HHS; R01 CA118750/CA/NCI NIH HHS; R01 HG004361/HG/NHGRI NIH HHS; R01-CA118750/CA/NCI NIH HHS; R01-HG004361/HG/NHGRI NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/RNA, Untranslated; 0/Ribonucleoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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