Document Detail


Genitourinary tuberculosis in a medical center in southern Taiwan: an eleven-year experience.
MedLine Citation:
PMID:  17066204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Genitourinary tuberculosis is the second most common disease form of extrapulmonary tuberculosis. This study analyzed the clinical characteristics and outcome in 31 patients with genitourinary tuberculosis treated between 1994 and 2004 at a tertiary medical center in southern Taiwan. METHODS: Data were collected by chart review. Diagnosis was based on microbiological or histological proof plus compatible radiographic findings and clinical presentation. RESULTS: This study included 14 men (45%) and 17 women (55%). Their ages ranged from 31 to 81 years (mean, 58.1 years). Genitourinary symptoms (83.9%) were more frequent than constitutional symptoms (35.5%). Pyuria plus hematuria with sterile culture (51.6%) was the most common finding. Only 25.8% of patients had a known history of pulmonary tuberculosis. Diagnosis was based on microbiological findings in 11 patients (35.5%), and by histological findings in 20 (64.5%) patients. Intravenous pyelography revealed abnormalities in 94% of patients and renal ultrasonography in 79.2%. Imaging studies were characteristic of advanced stage in most patients. Twenty-five percent of patients were classified as having treatment failure after at least 6 months of therapy. The treatment failure rate was higher in patients with positive microbiological findings (71.4%) than in those with histological findings alone (5.9%, p=0.003). CONCLUSIONS: The high rate of treatment failure and advanced stage of disease at diagnosis are indicative of the challenge in the care of patients with genitourinary tuberculosis in Taiwan.
Authors:
Hsiao-Cheng Hsieh; Po-Liang Lu; Yen-Hsu Chen; Tun-Chieh Chen; Jih-Jin Tsai; Ko Chang; Tyen-Po Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi     Volume:  39     ISSN:  1684-1182     ISO Abbreviation:  J Microbiol Immunol Infect     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-26     Completed Date:  2007-02-21     Revised Date:  2007-06-21    
Medline Journal Info:
Nlm Unique ID:  100956211     Medline TA:  J Microbiol Immunol Infect     Country:  China    
Other Details:
Languages:  eng     Pagination:  408-13     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antitubercular Agents / therapeutic use
Female
Hematuria / pathology
Humans
Male
Middle Aged
Mycobacterium tuberculosis / isolation & purification
Pyuria / pathology
Retrospective Studies
Taiwan
Tuberculosis, Pulmonary / complications
Tuberculosis, Urogenital / complications,  drug therapy,  microbiology,  pathology*
Chemical
Reg. No./Substance:
0/Antitubercular Agents

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