| Genitourinary anomaly in congenital varicella syndrome: case report and review. | |
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MedLine Citation:
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PMID: 15015072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a 1-year-old boy with congenital varicella syndrome who had vesicoureteral reflux (VUR) and neurogenic bladder. His mother had varicella during the 3rd month of pregnancy. At birth the patient presented with right microphthalmia, right microcornea, and persistent hyperplastic primary vitreous of the right eye. He had chronic constipation from 3 months of age. He had urinary tract infection at 1 year of age. Urological investigation revealed left grade V VUR and neurogenic bladder. His varicella zoster virus IgG titer measured by ELISA was 39.4 antibody index (normal <0.1). He had repeated episodes of urinary tract infection despite antibiotic prophylaxis and clean intermittent catheterization, and underwent a uretero-vesiconeostomy at 2 years of age. Maternal infection during early pregnancy and the serological evidence of varicella zoster IgG antibodies without a history of varicella after birth led to the diagnosis of congenital varicella syndrome. Urogenital anomalies have previously been described in 14 cases of congenital varicella syndrome. Most of these patients had neurogenic bladder, the pathophysiology of which could be explained by the known neurotropic nature of the virus. |
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Authors:
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Hisayo Fujita; Akira Yoshii; Jun Maeda; Kenjiro Kosaki; Seiichiro Shishido; Hideo Nakai; Midori Awazu |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2004-03-10 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 19 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-16 Completed Date: 2004-11-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 554-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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pathology Chickenpox / complications*, congenital* Constipation / complications Enzyme-Linked Immunosorbent Assay Humans Immunoglobulin M / biosynthesis, immunology Infant, Newborn Male Nervous System Diseases / congenital, etiology Urinary Bladder / radiography, virology Urinary Bladder, Neurogenic / etiology, pathology Urogenital Abnormalities / etiology*, pathology Vesico-Ureteral Reflux / etiology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin M |
| Comments/Corrections | |
Comment In:
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Pediatr Nephrol. 2004 Sep;19(9):1065
[PMID:
15221427
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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