| Genital tract methicillin-resistant Staphylococcus aureus: risk of vertical transmission in pregnant women. | |
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MedLine Citation:
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PMID: 18165399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To estimate the frequency of genital tract colonization by methicillin-resistant Staphylococcus aureus (MRSA) among pregnant women and evaluate the association of such colonization with infant outcome. METHODS: Between July 2003 and July 2006, anovaginal screening cultures for group B Streptococcus (GBS) were prospectively obtained in the third trimester (35 to less than 37 weeks of gestation) and were also processed for identification of Staphylococcus aureus including methicillin-resistant strains. Maternal colonization by MRSA was linked to a computerized database of invasive neonatal infections that occurred at our center during the study period. RESULTS: Among 5,732 mothers (who delivered 5,804 infants) with GBS screening cultures and infant infection data available, 22.9% were GBS-positive and 14.5% were positive for Staphylococcus aureus. A total of 24.3% of the Staphylococcus aureus isolates were MRSA. The overall MRSA colonization rate was 3.5%. Colonization by any Staphylococcus aureus (relative risk 1.6, 95% confidence interval 1.4-1.9) as well as MRSA (relative risk 2.2, 95% confidence interval 1.6-2.8) was significantly more common among GBS-positive than among GBS-negative women. No cases of early-onset invasive neonatal infection by MRSA occurred among infants in the study. CONCLUSION: Genital tract colonization with MRSA affected 3.5% of pregnant women. Such MRSA colonization is associated with colonization by GBS but does not predispose to a high risk of early-onset neonatal MRSA infection. LEVEL OF EVIDENCE: III. |
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Authors:
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William W Andrews; Robert Schelonka; Ken Waites; Alan Stamm; Suzanne P Cliver; Stephen Moser |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 111 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-31 Completed Date: 2008-02-14 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 113-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35249-7333, USA. wandrews@uab.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Academic Medical Centers Alabama / epidemiology Carrier State* Female Humans Infant, Newborn Infectious Disease Transmission, Vertical* Methicillin Resistance* Pregnancy Pregnancy Complications, Infectious / microbiology* Pregnancy Trimester, Third Prenatal Diagnosis Prevalence Staphylococcal Infections / epidemiology, genetics, transmission* Staphylococcus aureus / genetics, pathogenicity* Streptococcal Infections / diagnosis Streptococcus agalactiae / isolation & purification Vagina / microbiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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