Document Detail

Genital human papillomavirus infections in patients attending an inner-city STD clinic.
MedLine Citation:
PMID:  1658954     Owner:  NLM     Status:  MEDLINE    
One hundred and sixteen consecutive women attending a Baltimore City STD clinic were studied for the prevalence of human papillomavirus (HPV) infection of the genital tract using three criteria: presence of clinically recognized (visible) genital warts, cytopathologic evidence suggestive of HPV infection in a Papanicolaou smear, and analysis of cervical scrapes for genital tract HPV genomic sequences by Southern hybridization. The women were young (median age: 22 years) and more than 80% had a history of one or more STDs. The prevalences were 17% for visible warts, 41% for cytologic findings suggestive of HPV infection, and 12% for HPV DNA in cervical scrapes. Comparing the results of the three techniques, HPV DNA was found significantly more often in cytopathology-positive women than in cytopathology-negative women (18% vs. 5%, P = 0.05) and in women with visible warts than in women without visible warts (29% vs. 6%, P = 0.01). Visible warts were more common in women with HPV-DNA-positive cervical scrapes than in HPV-negative women (50% vs. 14%, P = .01). Although 52% of women were judged as infected by at least one of the three criteria, only 4% were infected by using all three criteria. The prevalence of infection was 23% if cytopathology alone was excluded as evidence of HPV infection. These results indicate the difficulty in an accurate estimation of the prevalence of HPV infections, even in a high-risk population.
J E Horn; G M McQuillan; K V Shah; P Gupta; R W Daniel; P A Ray; T C Quinn; E W Hook
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Sexually transmitted diseases     Volume:  18     ISSN:  0148-5717     ISO Abbreviation:  Sex Transm Dis     Publication Date:    1991 Jul-Sep
Date Detail:
Created Date:  1991-12-02     Completed Date:  1991-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7705941     Medline TA:  Sex Transm Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183-7     Citation Subset:  IM    
Johns Hopkins University, School of Medicine, Baltimore, Maryland.
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MeSH Terms
Baltimore / epidemiology
Blotting, Southern
Cervix Uteri / microbiology
Condylomata Acuminata / complications,  diagnosis,  epidemiology*
DNA, Viral / analysis
Genital Diseases, Female / complications,  diagnosis,  epidemiology*
Genital Neoplasms, Female / complications,  diagnosis,  epidemiology*
Nucleic Acid Hybridization
Papillomaviridae / genetics,  isolation & purification*
Sexually Transmitted Diseases / complications
Tumor Virus Infections / complications,  diagnosis,  epidemiology*
Urban Population
Vaginal Smears
Grant Support
Reg. No./Substance:
0/DNA, Viral

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