| Genetics of Sjögren's syndrome in the genome-wide association era. | |
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MedLine Citation:
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PMID: 22289719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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While Sjögren's syndrome (SS) is more common than related autoimmune disorders, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), scientific and medical research in SS has lagged behind significantly. This is especially true in the field of SS genetics, where efforts to date have relied heavily on candidate gene approaches. Within the last decade, the advent of the genome-wide association (GWA) scan has altered our understanding of disease pathogenesis in hundreds of disorders through the successful identification of novel risk loci. With strong evidence for a genetic component in SS as evidenced by familial aggregation of SS as well as similarities between SS and SLE and RA, the application of GWA approaches would likely yield numerous novel risk loci in SS. Here we review the fundamental scientific principles employed in GWA scans as well as the limitations of this tool, and we discuss the application of GWA scans in determining genetic variants at play in complex disease. We also examine the successful application of GWA scans in SLE, which now has more than 40 confirmed risk loci, and consider the possibility for a similar trajectory of SS genetic discovery in the era of GWA scans. Ultimately, the GWA studies that will be performed in SS have the potential to identify a myriad of novel genetic loci that will allow scientists to begin filling in the gaps in our understanding of the SS pathogenesis. |
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Authors:
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John A Ice; He Li; Indra Adrianto; Paul Chee Lin; Jennifer A Kelly; Courtney G Montgomery; Christopher J Lessard; Kathy L Moser |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-01-29 |
Journal Detail:
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Title: Journal of autoimmunity Volume: 39 ISSN: 1095-9157 ISO Abbreviation: J. Autoimmun. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-06-19 Completed Date: 2013-01-03 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8812164 Medline TA: J Autoimmun Country: England |
Other Details:
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Languages: eng Pagination: 57-63 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmunity Genetic Predisposition to Disease Genome, Human Genome-Wide Association Study* Humans Lupus Erythematosus, Systemic / genetics* Polymorphism, Single Nucleotide Sjogren's Syndrome / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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P30 AR053483/AR/NIAMS NIH HHS; P50 AR060804/AR/NIAMS NIH HHS; P50 AR060804-01/AR/NIAMS NIH HHS; R01 AR050782/AR/NIAMS NIH HHS; R01 AR050782-01/AR/NIAMS NIH HHS; R01 DE017589/DE/NIDCR NIH HHS; R01 DE018209/DE/NIDCR NIH HHS; R01 DE018209-01A1/DE/NIDCR NIH HHS; U19 A1082714//PHS HHS; U19 AI082714/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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