Document Detail


Genetics of the sudden infant death syndrome.
MedLine Citation:
PMID:  20674198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sudden infant death syndrome (SIDS) is currently defined as "the sudden unexpected death of an infant less than 1 year of age with onset of the fatal episode apparently occurring during sleep, that remains unexplained after a thorough investigation". SIDS, whose etiology remains rather vague, is still the major cause of death among infants between 1 month and 1 year of age in industrialized countries with varying incidences in different populations. Herein, after touching on definitory approaches and several current hypotheses concerning SIDS etiology, we focus on the triple risk model of SIDS and discuss two large classes of genetic factors potentially contributing to or predisposing for the generation of a vulnerable infant that, when encountering an environmental trigger, may succumb to SIDS. We conclude by acknowledging that for the integration of the vast and complex genetic evidence concerning SIDS, a lot more research will be required and we briefly discuss the potential use of recently presented animal models for functional studies of SIDS pathology.
Authors:
Cornelius Courts; Burkhard Madea
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Publication Detail:
Type:  Journal Article     Date:  2010-08-02
Journal Detail:
Title:  Forensic science international     Volume:  203     ISSN:  1872-6283     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-29     Revised Date:  2011-07-22    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  25-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Institute of Forensic Medicine, University of Bonn, Bonn, Germany. cornelius.courts@uni-bonn.de
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MeSH Terms
Descriptor/Qualifier:
Acyl-CoA Dehydrogenase / deficiency,  genetics
Adenosine Triphosphate / deficiency
Cytokines / genetics
DNA, Mitochondrial / genetics
Humans
Infant
Lipid Metabolism, Inborn Errors / complications,  genetics
Long QT Syndrome / genetics
Monoamine Oxidase / genetics
Muscle Proteins / genetics
Mutation
Polymorphism, Single Nucleotide
Potassium Channels / genetics
Serotonin Plasma Membrane Transport Proteins / genetics
Sodium Channels / genetics
Sudden Infant Death / etiology,  genetics*
Chemical
Reg. No./Substance:
0/Cytokines; 0/DNA, Mitochondrial; 0/Muscle Proteins; 0/Potassium Channels; 0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins; 0/Sodium Channels; 0/sodium channel protein type 5 subunit alpha; 56-65-5/Adenosine Triphosphate; EC 1.3.99.3/Acyl-CoA Dehydrogenase; EC 1.4.3.4/Monoamine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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