Document Detail


Genetics of sudden cardiac death in children and young athletes.
MedLine Citation:
PMID:  22824130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sudden cardiac death is a rare but socially devastating event. The most common causes of sudden cardiac death are congenital electrical disorders and structural heart diseases. The majority of these diseases have an incomplete penetrance and variable expression; therefore, patients may be unaware of their illness. In several cases, physical activity can be the trigger for sudden cardiac death as first symptom. Our purpose is to review the causes of sudden cardiac death in sportive children and young adults and its genetic background. Symptomatic individuals often receive an implantable cardioverter-defibrillator, the preventive treatment for sudden cardiac death in most of cases due to channelopathies, which can become a challenging option in young and active patients. The identification of one of these diseases in asymptomatic patients has similarly a great impact on their everyday life, especially on their ability to undertake competitive physical activities, and the requirement of prophylactic treatment. We review main causes of sudden cardiac death in relation to its genetics and diagnostic work-up
Authors:
Georgia Sarquella-Brugada; Oscar Campuzano; Anna Iglesias; Josep Sánchez-Malagón; Myriam Guerra-Balic; Josep Brugada; Ramon Brugada
Publication Detail:
Type:  Journal Article; Review     Date:  2012-07-24
Journal Detail:
Title:  Cardiology in the young     Volume:  23     ISSN:  1467-1107     ISO Abbreviation:  Cardiol Young     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-06-11     Completed Date:  2014-02-10     Revised Date:  2014-02-18    
Medline Journal Info:
Nlm Unique ID:  9200019     Medline TA:  Cardiol Young     Country:  England    
Other Details:
Languages:  eng     Pagination:  159-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Arrhythmias, Cardiac / complications,  genetics*
Asymptomatic Diseases
Athletes*
Cardiomyopathies / complications,  genetics*
Channelopathies / complications,  genetics*
Child
Child, Preschool
Death, Sudden, Cardiac / etiology*,  prevention & control
Defibrillators, Implantable
Exercise
Heart Arrest / genetics,  prevention & control
Humans
Infant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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