Document Detail

Genetics of the spondyloarthropathies.
MedLine Citation:
PMID:  1911054     Owner:  NLM     Status:  MEDLINE    
Following three decades of study of the genetics of the spondyloarthropathies by segregation analysis of families, research has increasingly made use of new methods of molecular genetics and immunology. In the past year, most attention has been given to the structure and function of HLA-B27, which, with its various subtypes, is the major phenotype contributing to susceptibility to this group of disorders. Structural studies have revealed which structures are responsible for the common antigenic properties and which are responsible for subtype specificities. Application of increasing understanding of the function of class I HLA antigens is permitting the development of various models of disease. Successful production of HLA-B27 transgenic animals holds promise for testing these models.
J C Woodrow
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  3     ISSN:  1040-8711     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-11-08     Completed Date:  1991-11-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  586-91     Citation Subset:  IM    
University of Liverpool, UK.
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MeSH Terms
Arthritis, Psoriatic / genetics
HLA-B27 Antigen / chemistry,  immunology
Joint Diseases / genetics*,  immunology
Spinal Diseases / genetics*,  immunology
Spondylitis, Ankylosing / genetics
Reg. No./Substance:
0/HLA-B27 Antigen

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