| Genetics of proliferative aging. | |
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MedLine Citation:
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PMID: 17049783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human lifespan is limited by aging of both mitotic and post-mitotic cells. These two forms of aging may occur by distinct or overlapping mechanisms. Telomere erosion has been shown to limit the proliferative lifespan of human somatic cells. Other vertebrates, such as mice, possess robust telomerase activity in most cell types and their somatic cells display finite replicative lifespans as a consequence of other forms of macromolecular damage. Genetic analysis in humans, mice and yeast has provided clues regarding pathways that may affect a cell's replicative lifespan. In addition, analysis of the means by which germ cells maintain their effervescent character may provide a deeper understanding of how replicative aging occurs in somatic cells. |
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Authors:
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Theresa Zucchero; Shawn Ahmed |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2006-10-17 |
Journal Detail:
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Title: Experimental gerontology Volume: 41 ISSN: 0531-5565 ISO Abbreviation: Exp. Gerontol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-12-04 Completed Date: 2007-11-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
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Languages: eng Pagination: 992-1000 Citation Subset: IM |
Affiliation:
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Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-3280, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Aging / genetics* Cell Division / genetics DNA Damage / genetics Germ Cells / physiology Humans Longevity / genetics Mammals / genetics, physiology Mice Progeria / genetics, physiopathology RNA / genetics Saccharomyces cerevisiae / genetics, physiology Telomere / genetics |
| Grant Support | |
ID/Acronym/Agency:
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GM 00678/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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