Document Detail

Genetics of proliferative aging.
MedLine Citation:
PMID:  17049783     Owner:  NLM     Status:  MEDLINE    
Human lifespan is limited by aging of both mitotic and post-mitotic cells. These two forms of aging may occur by distinct or overlapping mechanisms. Telomere erosion has been shown to limit the proliferative lifespan of human somatic cells. Other vertebrates, such as mice, possess robust telomerase activity in most cell types and their somatic cells display finite replicative lifespans as a consequence of other forms of macromolecular damage. Genetic analysis in humans, mice and yeast has provided clues regarding pathways that may affect a cell's replicative lifespan. In addition, analysis of the means by which germ cells maintain their effervescent character may provide a deeper understanding of how replicative aging occurs in somatic cells.
Theresa Zucchero; Shawn Ahmed
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2006-10-17
Journal Detail:
Title:  Experimental gerontology     Volume:  41     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  992-1000     Citation Subset:  IM    
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
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MeSH Terms
Cell Aging / genetics*
Cell Division / genetics
DNA Damage / genetics
Germ Cells / physiology
Longevity / genetics
Mammals / genetics,  physiology
Progeria / genetics,  physiopathology
RNA / genetics
Saccharomyces cerevisiae / genetics,  physiology
Telomere / genetics
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