Document Detail


Genetics of perinatal brain injury in the preterm infant.
MedLine Citation:
PMID:  16368523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Due to developmental immaturity of the central nervous system, effects of an adverse intrauterine environment and need for intensive care postnatally, preterm infants are at high risk of sustaining brain injury in the perinatal period. Infants who suffer brain injury in the perinatal period are at risk for long-term neurodevelopmental sequelae. Clinical and experimental data supports a significant role for inflammatory mediators in the pathophysiology of perinatal brain injury. Abnormalities in coagulation proteins in the sick preterm newborn may accentuate the risk for intraventricular hemorrhage. Polymorphisms in TNF alpha , IL-1 beta , IL-4, IL-6 and IL-10 as well as mutations in coagulation proteins have been investigated as potential candidate genes to modify risk and or severity of perinatal brain injury. Preliminary evidence suggests a role for cytokine genes as risk modifiers for IVH and PVL.
Authors:
Ronald John Baier
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-05-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  11     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2006  
Date Detail:
Created Date:  2005-12-21     Completed Date:  2006-06-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1371-87     Citation Subset:  IM    
Affiliation:
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, R3E 0L8, Canada.
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MeSH Terms
Descriptor/Qualifier:
Brain / embryology*,  pathology
Brain Injuries / genetics*
Central Nervous System / pathology*
Cytokines / metabolism
Gene Expression Regulation*
Genetic Predisposition to Disease*
Genetic Variation
Hemorrhage / metabolism
Humans
Infant, Newborn
Infant, Premature
Inflammation
Interleukin-1 / genetics
Interleukin-10 / genetics
Interleukin-4 / genetics
Interleukin-6 / genetics
Intracranial Hemorrhages
Leukomalacia, Periventricular / metabolism
Mutation*
Polymorphism, Genetic*
Risk
Thrombophilia / pathology
Tumor Necrosis Factor-alpha / genetics,  metabolism
Chemical
Reg. No./Substance:
0/Cytokines; 0/Interleukin-1; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 207137-56-2/Interleukin-4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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