Document Detail

Genetics and pathogenesis of inflammatory bowel disease.
MedLine Citation:
PMID:  21677747     Owner:  NLM     Status:  MEDLINE    
Recent advances have provided substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bowel disease. Cellular programs responsible for intestinal homeostasis use diverse intracellular and intercellular networks to promote immune tolerance, inflammation or epithelial restitution. Complex interfaces integrate local host and microbial signals to activate appropriate effector programs selectively and even drive plasticity between these programs. In addition, genetic studies and mouse models have emphasized the role of genetic predispositions and how they affect interactions with microbial and environmental factors, leading to pro-colitogenic perturbations of the host-commensal relationship.
Bernard Khor; Agnès Gardet; Ramnik J Xavier
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-06-15
Journal Detail:
Title:  Nature     Volume:  474     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-16     Completed Date:  2011-07-26     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  307-17     Citation Subset:  IM    
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MeSH Terms
Epithelium / immunology,  metabolism,  microbiology
Genetic Predisposition to Disease*
Immunity, Innate / immunology
Inflammatory Bowel Diseases / genetics*,  immunology,  microbiology,  physiopathology*
Grant Support
P30 DK040561/DK/NIDDK NIH HHS; P30 DK040561-15/DK/NIDDK NIH HHS; P30 DK043351/DK/NIDDK NIH HHS; P30 DK043351-20/DK/NIDDK NIH HHS; R01 DK083756/DK/NIDDK NIH HHS; R01 DK083756-04/DK/NIDDK NIH HHS

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