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Genetics of occupational asthma.
MedLine Citation:
PMID:  21325943     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: To discuss gene association studies conducted in workers diagnosed with occupational asthma. RECENT FINDINGS: Human leukocyte antigen studies conducted in European workers have defined major histocompatibility complex class II alleles and haplotypes associated with diisocyanate asthma. Recently, certain glutathione S-transferase genotypes (e.g. the GSTM1 null genotype) and N-acetyltransferase genotypes associated with slow acetylation phenotypes have been reported to be associated with diisocyanate asthma. Genotype combinations of IL-4 receptor-α and CD14 single nucleotide polymorphisms (SNPs) were significantly associated with diisocyanate asthma, but only in workers exposed to hexamethylene diisocyanate. A recent genome-wide association study (GWAS) conducted in Korea identified several SNPs of the α-T-catenin gene that were significantly associated with diisocyanate asthma. SUMMARY: Although candidate gene association studies have yet to identify reliable predictors of occupational asthma, future investigations including GWAS studies may identify high-risk genotypes allowing identification of workers at risk.
Authors:
David I Bernstein
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-15
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  -     ISSN:  1473-6322     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Immunology, Allergy and Rheumatology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
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