| Genetics of multiple sclerosis. | |
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MedLine Citation:
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PMID: 14747002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple sclerosis (MS) is probably aetiologically heterogeneous. Systematic genetic epidemiological and molecular genetic studies have provided important insights. Both genetic and non-genetic (environment, stochastic) factors may be involved in susceptibility as well as outcome, but we have yet to understand their relative roles. Any environmental factor is likely to be ubiquitous and act on a population-basis rather than within the family microenvironment. Taken together, the results of genome screening studies provide strong evidence for exclusion of a major locus in MS. There are, however, many genes that seem to be associated with MS. These include, but are in no way limited to, HLA classes I and II, T-cell receptor beta, CTLA4, ICAM1, and SH2D2A. The future of MS genetics, as for most common complex disorders, will be dependent on the resources available, ranging from biological samples and comprehensive databases of clinical and epidemiological information to the development of new technologies and statistical methods. |
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Authors:
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David A Dyment; George C Ebers; A Dessa Sadovnick |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Lancet neurology Volume: 3 ISSN: 1474-4422 ISO Abbreviation: Lancet Neurol Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-01-28 Completed Date: 2004-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101139309 Medline TA: Lancet Neurol Country: England |
Other Details:
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Languages: eng Pagination: 104-10 Citation Subset: IM |
Affiliation:
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The Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD Antigens, Differentiation / genetics Female Genes, T-Cell Receptor beta / genetics Genetic Predisposition to Disease* Humans Linkage (Genetics) Major Histocompatibility Complex / genetics Male Multiple Sclerosis / genetics* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation; 0/cytotoxic T-lymphocyte antigen 4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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