Document Detail


Genetics (molecular biology) and Meniere's disease.
MedLine Citation:
PMID:  12486836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
COCH is not the FMD gene detected in our linkage study; furthermore, COCH and FMD are not allelic. The indications are that FMD is heterogenetic. The linkage analysis points to the possibility of one FMD mutation in one of the neighboring candidate genes on chromosome 14, and, with anticipation, possibly a triple repeat amplification. Recently, the myotonic dystrophy type 2 locus has been shown to contain an expanded tetranucleotide repeat [46], so the search for a similar repeat on 14q is indicated.
Authors:
Andrew W Morrison; Keith J Johnson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Otolaryngologic clinics of North America     Volume:  35     ISSN:  0030-6665     ISO Abbreviation:  Otolaryngol. Clin. North Am.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-12-18     Completed Date:  2003-01-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0144042     Medline TA:  Otolaryngol Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  497-516     Citation Subset:  IM    
Affiliation:
Royal London Hospital, London, UK. a.morrison@which.net
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Animals
Chi-Square Distribution
Child
Chromosomes, Human, Pair 14 / genetics
Electroencephalography
Female
Gene Amplification
Genetic Predisposition to Disease
HLA Antigens / genetics
Humans
Linkage (Genetics)
Male
Meniere Disease / complications,  genetics*
Middle Aged
Migraine Disorders / complications,  genetics
Mutation
Pedigree
Questionnaires
Risk
Trinucleotide Repeats
Chemical
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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